Scenario D. Cystic fibrosis is à genetic descent. It is caused by a rare recessive allele at a gene that exhibits complete dominance (N = norm= allele, C = disease allele). You sample 1000 European descendants in a U.S. population and find 772 NN individuals, 221 NC heterozygotes, and 7 CC individuals with cystic fibrosis. %3D
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- Cystic fibrosis is an autosomal recessive disease characterized by two copies of a mutated CFTR gene. If one in 100 (hypothetical scenario, not reality) people in the United States have cystic fibrosis, calculate the p and q frequency for the normal allele (p) and the mutated allele (q). Based on those calculations, what percentage of individuals would be expected to be homozygous dominant?A mutation in an of the recessive hemoglobin gene on chromosome 11 causes sickle-cell disease, but also confers malaria resistance. The allele frequency in African Americans is 14%. 1. What percent of the population have two copies of the gene and are therefore immune to malaria? 2. What percent of the population are less susceptible to malaria but do not have sickle-cell anemia since they are heterozygous?Heterozygote advantage is an interesting condition in those individuals who have one of each allele (dominant and recessive) have a higher survival rate than those individuals who are either homozygous dominant or homozygous recessive. Sickle-cell anemia is such a genetic disease associated with the recessive allele. Normal homozygous individuals (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to…
- Below in Figure 1 is a pedigree for a family afflicted by a genetic disorder. In some populations, Cystic fibrosis has an incidence of 1 in 2500 newborns. The carrier frequency calculated from this is 1/25. Analyze the pedigree below assuming the disease is similar to cystic fibrosis in incidence and carrier frequency. However this disease may not have the same type of genetic transmission as cystic fibrosis. What type of genetic transmission is most consistent with the pedigree? Label all the individuals that you can determine, with hypothesized genotypes. Label the individuals that have unknown genotypes with possible genotypes. Assuming her father is known to NOT be a carrier, calculate the probability that IV1 is a carrier for disease. Use the Χ2 test to determine whether your proposed transmission fits this data.Identify each of the following as an example of allele, genotype,and/or phenotype frequency:A. Approximately 1 in 2500 individuals of Northern Europeandescent is born with cystic fibrosis.B. The percentage of carriers of the sickle cell allele in WestAfrica is approximately 13%.C. The number of new mutations per generation resultingin achondroplasia, a genetic disorder, is approximately5 × 10−5.In humans, the genetic disease cystic fibrosis is caused by a recessive allele (a). The normal (healthy) allele is dominant (A). What is the genotype of someone who has cystic fibrosis? What are the two different genotypes that a healthy person could have? If two people were both heterozygous for the cystic fibrosis gene, what fraction of their children would be likely to have this disease? Hint: Draw a Punnett square to figure it out.
- Allele B is a deleterious autosomal dominant. The frequency of affected individuals is 4.0 × 10−6. The reproductive capacity of these individuals is about 30 percentthat of normal individuals. Estimate μ, the rate at whichb mutates to its deleterious allele B. Assume that the frequencies of the alleles are at their equilibrium values.. As we learned in this chapter, the white mutation ofDrosophila studied by Thomas Hunt Morgan isX-linked and recessive to wild type. When truebreeding white-eyed males carrying this mutationwere crossed with true-breeding purple-eyed females,all the F1 progeny had wild-type (red) eyes. When theF1 progeny were intercrossed, the F2 progeny emergedin the ratio 3/8 wild-type females: 1/4 white-eyedmales: 3/16 wild-type males: 1/8 purple-eyed females:1/16 purple-eyed males.a. Formulate a hypothesis to explain the inheritanceof these eye colors.b. Predict the F1 and F2 progeny if the parental crosswas reversed (that is, if the parental cross wasbetween true-breeding white-eyed females andtrue-breeding purple-eyed males).Consider the MN blood system in humans. This blood system consists of only two alleles, M and N, and they are codominant to each other. Three genotypes are possible, and these genotypes can be easily identified through simple blood typing procedures, including the heterozygous MN due to the codominant mode of inheritance. Consider the following data: Phenotype Genotype Number of individuals M MM 89 MN MN 162 N NN 79 1. How many alleles exist in this population? 2. What is the genotypic frequency of the M blood type in the population? 3. What is the allelic frequency of M? 4. What is the allelic frequency of N? 5. What is the genotypic frequency of MN? Write your answers directly. You do not need to show your solution.
- Cystic fibrosis (CF) is an inherited chronic disease that affects the lungs and digestive system of about 30,000 children and adults in the United States. It is caused by a recessive allele that encodes a defective chloride channel. Genetic screening has determined that two parents are carriers (heterozygous). What is the probability that they have a child with CF? Rabbits with the genotype CC° are black, heterozygous rabbits CCW appear brown, and rabbits that are CWC" have white fur. VWhat is the phenotypic and genotypic ratio of the offspring of a cross between a brown and a white rabbit? Using your book, determine the probability of each blood type in the offspring of a heterozygous man who has type B blood, and a heterozygous woman who has type A blood. A woman who is type O gives birth to a baby who is also type 0. In a paternity case, a man claims that he cannot be the father because he has type A blood. Is he right? Explain.The allele of the gene responsible for the lung disorder, cystic fibrosis rose to prominence in Europe in the 1800s. Cystic fibrosis disease results from thick mucus accumulating in the lungs, which occurs in individuals who are homozygous for the CF allele. A pleiotropic effect is that heterozygous individuals are less likely to suffer from diarrhea. During the European cholera epidemics of the 1800s, resistance against diarrhea conferred a survival advantage such that approximately one in every 400 people in some European populations have cystic fibrosis. Fill in the table below with the genotype and allele frequencies for this 1 in 400 occurrence and provide the Hardy-Weinberg principle model you will be using. (Assume that individuals with the cystic fibrosis trait (CF) reproduce normally and that good sanitation means that there is currently no fitness advantage to diarrhea resistance.) phenotype CF DR normal (totals) Genotype cc Cc CC Number of Individuals 1 ______…Albinism is a recessive trait in humans. A geneticist studies families in which both parents are normal and at least one child has albinism. The geneticist reasons that both parents in these families must be heterozygous and the albinism should appear in 1⁄4 of the children of these families. To his surprise, the geneticist finds the frequency of albinism trait is quite high. As a consultant, can you suggest an explanation for the higher expected frequency of albinisms in these families?