Synthesis of Ibuprofen-Part 2: 1. Some pain relievers including ibuprofen (MotrinⓇ) and naproxen (AleveⓇ) are "α-arylpropanoic acids." Look up the structure of flurbiprofen, another α-arylpropionic acid. Using the same reactions that we used for making ibuprofen, show how to make flurbiprofen from the compound below. Show all intermediates and reagents in your synthesis. F 2. Show how you would prepare ibuprofen starting from p-isobutylbenzaldehyde rather than p-isobutylacetophenenone. What reaction steps would need to change and how?

Synthesis of Ibuprofen-Part 2: 1. Some pain relievers including ibuprofen (MotrinⓇ) and naproxen (AleveⓇ) are "α-arylpropanoic acids." Look up the structure of flurbiprofen, another α-arylpropionic acid. Using the same reactions that we used for making ibuprofen, show how to make flurbiprofen from the compound below. Show all intermediates and reagents in your synthesis. F 2. Show how you would prepare ibuprofen starting from p-isobutylbenzaldehyde rather than p-isobutylacetophenenone. What reaction steps would need to change and how?

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter10: Alcohols

Section: Chapter Questions

Problem 10.50P

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Synthesis of Ibuprofen-Part 2: Some pain relievers including ibuprofen (Motrin®) and naproxen (Aleve®) are "a-arylpropanoic acids." Look up the structure of flurbiprofen, another a-arylpropionic acid. Using the same reactions that we used for making ibuprofen, show how to make flurbiprofen from the compound below. Show all intermediates and reagents in your synthesis. 1. F
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