Synthesis of the purine nucleotides AMP andGMP proceeds by a branched pathway starting with ribose5-phosphate (R5P), as shown schematically in FigureQ3–4. Using the principles of feedback inhibition, proposea regulatory strategy for this pathway that ensures an ade-quate supply of both AMP and GMP and minimizes thebuildup of the intermediates (A–I) when supplies of AMPand GMP are adequate.

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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Synthesis of the purine nucleotides AMP and
GMP proceeds by a branched pathway starting with ribose
5-phosphate (R5P), as shown schematically in Figure
Q3–4. Using the principles of feedback inhibition, propose
a regulatory strategy for this pathway that ensures an ade-
quate supply of both AMP and GMP and minimizes the
buildup of the intermediates (A–I) when supplies of AMP
and GMP are adequate.

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