The development of colon cancer is particularly well- studied, and often has a predictable order of mutations. Briefly describe the most common steps in the progression of colon cancer in the order of key genes mutated.
Q: what is the diagnosis of Chronic granulomatous disease (CGD) and explain the genetic mechanism…
A: Bridges-Good syndrome is another name for chronic granulomatous disease (CGD). The distinctive…
Q: List two dietary factors associated with an increased risk of cancers of the colon and rectum.
A: Cancer is a genetic disease. It is not a single disease; it is two or more hundred diseases. It…
Q: Glioblastoma multiforme (GBM) is the most commonand aggressive form of brain cancer in…
A: The EGFR is a transmembrane protein. The N (amino) terminal of EGFR protein has an extracellular…
Q: Please explain how aneupolidy can lead to cancer
A: INTRODUCTION Aneuploidy It is a condition in which haploid set chromosome have abnormal number of…
Q: Compare and contrast between the treatment of lung cancer and colorectal cancer? Please answer at…
A: Lung cancer and colorectal cancer are malignancy seen in two separate organs. Lung cancer affect the…
Q: Explain why the signs of colorectal cancer vary with thelocation of the tumor.
A: Colorectal cancer is any type of cancer that affects colon and rectum. This type of cancer stand…
Q: Certain types of cancer can lead to humoral hypercalcemiaof malignancy. True or false?
A: Cancer is a disease that is associated with the uncontrolled division of cells and invasion of…
Q: 34. Explain the mechanism of action of tamoxifen in the treatment of breast cancer.
A: We know that Breast cancer develops as any of the cells in the breast tend to expand abnormally.…
Q: explain this diagram of cervical histology of cancer
A: Cancer is a condition, where cells in a particular tissue or organ start to divide and proliferate…
Q: Identify the common types of cancers and the body system with which each is associated.
A: The cells of the body differentiate after the division to perform different functions. Some of the…
Q: Explain several ways by which the treatment of cancer by chemotherapy may temporarily create…
A: Cells that grow indefinitely are referred to as cancer cells. These cells are not controlled during…
Q: Briefly describe the disease and provide the most common symptoms/features of Chronic Myelogenous…
A: Definition:- Chronic myelogenous leukemia (CML) is an uncommon type of cancer of the bone marrow —…
Q: a. Explain why the lung is a common site forsecondary cancer.b. State two systemic signs or symptoms…
A: Tumors that can spread from almost anywhere in the body to our lungs are known as primary tumors.…
Q: Which type of cancer has been treated with ipilumumab?With what success?
A: The immune system of the body protects the individual from the attack of external pathogens. The…
Q: /hich type of colorectal cancer is considered to be an autosomal dominant disorder haracterized with…
A: Colorectal cancer is any cancer that affects the colon and the rectum. It acts as a growth on the…
Q: Briefly outline some of the genetic changes commonly associated with the progression of colorectal…
A: Cancer is a disease in which abnormal cells divide uncontrollably and destroy body tissue. The most…
Q: Define E-cadherin activity is lostduring the epithelial-to-mesenchymal transition and during…
A: Introduction: Cadherins are a type of molecule that helps in cell adhesion and is named so for their…
Q: Development of cancer is a multi-step process; a.How does information on the onset of cancer agree…
A: Development of cancer takes place by the growth of mass due to abnormal changes occurring in a cell.…
Q: Describe the major clinical manifestations of cancer.
A: Cancer is the state in which the cells exhibit uncontrolled cell division.
Q: What is the physiological effects of pancreatic cancer at the cellular, tissue and organ system
A: Since we answer only one question at a time, therefore we are answering the first one listed here.…
Q: Introductin of infectious agents and oncogenesis. Identify at least five infectious agent that play…
A: Infectious agents are organisms that are capable of producing infection or infectious disease. There…
Q: What is a good conclusion for causes of colon cancer ?
A: The digestive system includes the colon and rectum. The large intestine is a long, muscular tube…
Q: a) Discuss the role of Wnt pathway in the normal development of epithelia within the colon – stem…
A: *Wnt Pathway signalling has many functions like proliferation differentiation apoptosis…
Q: Name the misfolded protein associated with each of the following diseases: Alzheimer’s,…
A: The sequence of amino acids makes the primary structure of the protein. The primary structure folds…
Q: What are the treatments of colon cancer explaining them in a substantial way
A: Colon cancer It is defined as growth of abnormal cells in the colon characterized by cellular…
Q: #6) Histological work suggests that colon cancer develops in a multistep fashion. Which of the…
A: ANSWER) (5) a, b and c Colonoscopy is the medical procedure for detecting the abnormal changes in…
Q: explain what is macrotaxonomy?
A: A P Candolle proposed the term "taxonomy" in 1813 for the first time.
Q: The growth fraction of the cancer types A 8, C, and D are 23%, 45, 56%, and 78%, respectively. Which…
A: Fast-growing cells would be affected the most and slow-growing cells would be least disturbed. In…
Q: Can the proteomic fingerprint help determine if a given cancer is resistant or sensitive to a…
A: Proteomic fingerprint is an approach that depends on the patterns of the proteins observed but…
Q: Describe two mutations that are associated with the development of leukaemia and how these two…
A: The type of cancer that will begin in the blood-forming tissue, generally in the bone marrow, is…
Q: . Children with germline retinoblastoma are more likely to develop other primary malignancies in…
A: Retinoblastoma is a rare cancer usually initiated by biallelic mutation of the retinoblastoma gene…
Q: Hereditary retinoblastoma generally affects children in both eyes, while spontaneous retinoblastoma…
A: Retinoblastoma is defined as a type of cancer that starts in the retina and is located in the back…
Q: Write down the etiopathology and pathophysiology of breast cancer?
A: I am answering the first question please kindly repost the second question according to community…
Q: Hello! Describe xenophagy and discuss its onco-suppressive function (in details).
A: Gene therapy is a form of therapy that involves the use of genes to treat diseases. To fight cancer,…
Q: Inactivation of p16 in the carcinogenesis of Pancreatic AdenoCA, occurs with what stage of…
A: p16 is a tumor suppressor protein encoded by the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene…
Q: Explain why PID is considered a serious condition.
A: PID (pelvic inflammatory disease) is an infections of the reproductive organ in woman. It is a…
Q: How do the various types of leukemia, lymphoma, and plasma cell myelomas differ based on malignant…
A: To differentiate Various types of leukemia, lymphoma, and plasma cell myelomas differ based on…
Q: What is the relationship between DM and development of Pancreatic Cancer? How can we prepare…
A: Diabetes mellitus and some tumors have been linked in epidemiological research. Diabetes mellitus…
Q: Explain several ways by which the treatment of cancer by che-motherapy may temporarily create…
A: Chemotherapy is for treatment of cancer patients. chemotherapy drugs are generally act on the cells…
Q: Mutation in which of the following genes is most prevalent in human colorectal cancer cells?…
A: Answer. A normal cell undergoes regulated division, differentiation, and apoptosis. When normal…
Q: Discuss the spread of malignant tumors by invasion,metastasis, and seeding and relate them to the…
A: Introduction:- Malignant tumors have cells that grow uncontrollably and spread locally and/or to…
Step by step
Solved in 2 steps
- Duchenne muscular dystrophy describe the function of the gene and gene product as well as the phenotype (clinical picture). Explain how mutations in the gene and protein could contribute to the observed phenotype. Discuss the protein structures associated with the condition. How is it helpful in understanding gene’s function and in possible explaining of the pathology.explain and analyse each gene mutaition in the CIN, MSI, CIMP pathways and what are the causes of these mutations in regards to adenocarcinoma tumours colorectal cancer. Provide detailed analysis with examplesExplain the multi hit approach to colorectal cancer regarding the pathways CIN chromosomal instability (CIN), microsatellite instability (MSI). explain step by step. what genes are involved.
- What is the sequential pattern of mutations commonly observed in the development of colorectal adenocarcinoma, and how do these genetic alterations contribute to tumorigenesis and disease progression? Discuss key genes and signaling pathways involved, including APC, KRAS, and TP53 and describe how these mutations disrupt normal cellular functions and promote uncontrolled growth in colorectal cancer.According to the American Cancer Society, colon cancer screening should begin at age 50 for people at average risk. Imagine you have a family history of colon cancer. From your research, with reasons which procedures would your physician order for you and at what age ?Explain Three mechanisms for viral induction of cancer.
- Which of the following effectively describes the situation of someone with an inherited predisposition to cancer such as familial adenomatous polyposis or BRCA-associated familial breast cancer? Choose all that apply a) If they get malignant cancer, somatic mutations will not have been a factor b) Their cancer will most likely arise in their germ cells, not their somatic cells c) None of the answers effectively describes the situation d) Every cell of their body contains a gain-of-function allele of an oncogene e) Most cells in their body contain multiple cancer-causing mutations f) Every cell of their body contains a defective, loss-of-function allele of a tumor suppressor geneHereditary retinoblastoma generally affects children in both eyes, while spontaneous retinoblastoma usually occurs during adulthood only in one eye. Explain the genetic basis for the epidemiological distinction between these two forms of retinoblastoma. Explain the apparent paradox: loss-of-function mutations in tumor-suppressor genes act recessively, yet hereditary retinoblastoma is inherited as an autosomal dominant.what is the diagnosis of Chronic granulomatous disease (CGD) and explain the genetic mechanism involved. *do not plagiarized*
- Describe how mutations in genome maintenance factors promote tumorigenesis. Why would inactivation of a mis- match repair gene cause colon cancer?For the following diseases, describe the best technique for diagnosing them. Please make sure you include how you would tell someone with the disease from someone without the disease. B. Factor V Leiden thrombophilia is caused by a point mutation at position 1691 in exon 10 of the Factor V clotting factor gene that changes an arginine into a glutamine. This change removes one of the cleavage sites for activated protein C and leads to an increased tendency to clot.1. Describe & explain the pathophysiology of cancer based on the diagram. Reference: https://www.onlinebiologynotes.com/cancer-etiology-pathophysiology-types-diagnosis-and- treatment/ Acquired (environmental) DNA damaging agents: • chemical • radiation viruses Activation of growth- promoting oncogenes NORMAL CELL DNA Damage Failure of DNA repair Mutations in the genome of somatic cells Alteration of genes that regulate apoptosis Malignant neoplasm / Successful DNA repair CANCER Inherited mutations: • Genes affecting DNA repair • Genes affecting cell growth Expression of altered gene products and loss of regulatory gene products Inactivation of cancer suppresor genes Clonal expansion Additional mutations (progression) T Heterogeneity