The enormous complexity in initiating eukaryotic gene transcription seems at first glance to be wasteful. What is the most plausible reason for requiring so many different proteins to assemble a large array of DNA sequences in order to initiate transcription? The use of large numbers of proteins and regulatory sequences in DNA opens many possibilities for sophisticated combinatorial gene regulation O The need to open chromatin for transcription demands a much larger number of proteins and regulatory sequences in DNA O The use of large numbers of proteins and regulatory sequences in DNA is essential for alternative splicing of hnRNA in eukaryotes O The larger number of eukaryotic genes demands a correspondingly larger transcription apparatus than that of prokaryotes O The larger size of eukaryotic cells demands a correspondingly larger transcription apparatus than that of prokaryotes

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