The first genetic test used a short DNA sequence that was closely linked to the Huntington’s locus. The linkage distance between the DNA sequence used in the test and the actual Huntington’ disease locus was 5%. a. In a large sample of the Venezuelan family (over 2,000 individuals), what percentage of people would inherit the DNA sequence but not the Huntington’s allele (i.e. be a false positive test for Huntington’s)? b. What percentage of that large Venezuelan family would not inherit the DNA sequence but would inherit the Huntington’s allele (i.e., be a false negative test for Huntington’s)?

The first genetic test used a short DNA sequence that was closely linked to the Huntington’s locus. The linkage distance between the DNA sequence used in the test and the actual Huntington’ disease locus was 5%. a. In a large sample of the Venezuelan family (over 2,000 individuals), what percentage of people would inherit the DNA sequence but not the Huntington’s allele (i.e. be a false positive test for Huntington’s)? b. What percentage of that large Venezuelan family would not inherit the DNA sequence but would inherit the Huntington’s allele (i.e., be a false negative test for Huntington’s)?

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Description: 1. The first genetic test used a short DNA sequence that was closely linked to the Huntington’s locus. The linkage distance between the DNA sequence used in the test and the actual Huntington’ disease locus was 5%.a. In a large sample of the Venezuel

Biology: The Unity and Diversity of Life (MindTap Course List)

14th Edition

ISBN:9781305073951

Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Chapter13: Observing Patterns In Inherited Traits

Section: Chapter Questions

Problem 7SQ

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1. a) If you were at risk of a fatal disease such as Huntington’s disease and only the 95% accurate preliminary genetic test was available, would you take the test? After all, 95% of the time the test would tell you whether you would eventually get Huntington’s disease or whether you did not have to worry about getting this disease. b) The linkage distance between the DNA sequence used in the test and the actual Huntington’ disease locus was 5%. In a large sample of the Venezuelan family, what percentage of people would inherit the DNA sequence but not the Huntington’s allele (i.e. be a false positive test for Huntington’s)? What percentage of that large Venezuelan family would not inherit the DNA sequence but would inherit the Huntington’s allele (i.e., be a false negative test for Huntington’s)?
1. The first genetic test used a short DNA sequence that was closely linked to the Huntington’s locus. People taking the test were classified as to whether they had the DNA sequence that was linked to the Huntington’s disease. This method was 95% accurate. This means that 95% of the people who had the Huntington’s-linked DNA sequence actually inherited the Huntington allele. It also meant that 95% of the people who did not have the DNA sequence linked to the Huntington allele did not inherited the wild-type allele (not the Huntington allele).Why might this preliminary test not be as accurate as a gene test for the actual Huntington’s allele? Explain.
1. The frequency of a recessive disease is 9%. What is the frequency of the allele that causes s the disease? a) What is the frequency of the dominant allele? b) What is the frequency of the carriers (heterozygotes) of the disease?
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1.What would you predict would happen if you added Anti-A serum to this type of blood? 2. What would you predict would happen if you added Anti-B serum to this type of blood?3. Why is the genotype that codes for this blood type considered “codominant”?Please answer all of them now and do it
The linkage distance between the DNA sequence used in the test and the actual Huntington’ disease locus was 5%. In a large sample of the Venezuelan family, what percentage of people would inherit the DNA sequence but not the Huntington’s allele (i.e. be a false positive test for Huntington’s)? What percentage of that large Venezuelan family would not inherit the DNA sequence but would inherit the Huntington’s allele (i.e., be a false negative test for Huntington’s)?
8. Huntington’s disease is a degenerative disease of the nervous system that strikes in middle age. The allele that causes the disease (H) is dominant to the allele that results in the normal condition (h). Answer the following questions about the inheritance of this disease. A. What is the genotype of a man who is normal but whose father had Huntington’s disease? B. What is the genotype of a woman who has Huntington’s disease if both of her parents had Huntington’s disease? C. If a man who is heterozygous for Huntington’s disease marries a woman who is normal, what would you expect for the genotypes and phenotypes of their children? D. If a normal man marries a woman who is homozygous for Huntington’s disease, what do you expect for the genotypes and phenotypes of their children?
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2. Anyone who inherits a single copy of the Huntington’s allele will get Huntington’s disease, if they live long enough. The age of onset of Huntington’s symptoms for those who inherit the disease allele can vary, starting in the patients’ 40s, 50s, or 60s. What is the genetic term for this variation in symptoms and in their time of appearance?
1. A mother with blood type A has a child with blood type O, and she claims that Mister X is the father. Mister X denies that he could possibly be the father, because he has blood type B. If you were the judge presiding over this case, which of the following arguments would you find most convincing? a. Mr. X could be the father if his blood genotype is IBIB, and the mother’s blood genotype is IAIA b. Mr. X cannot be the father because a child with blood type O cannot have a parent with blood type B c. Mr. X could be the father if his blood genotype is IBi, and the mother’s blood genotype is IAi d. Mr. X cannot be the father because a parent with blood type B cannot have a child with blood type O e. Mr. X cannot be the father because the human ABO blood types are sex-linked traits 2. A monohybrid cross between two pea plants producing yellow peas, resulting in an F1 phenotypic ratio of 3:1 (three yellow pea plants to one green pea plant) indicates what about the parental pea plants?…
1. Develop a micro-theme to include the following concepts: a. Differentiate between genetics and heredity b. Compare dominant and recessive traits c. Compare pure and hybrid offspring
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