The following structure is more active than morphine as ananalgesic.H3CCH3H.H3C'O Il..What is the principal reason for this?The extra acetyl group binds to cell surface receptors improvingactive internalization.The acetyl groups mask a polar group allowing the structure tocross the blood brain barrier more efficiently.The extra acetyl group masks an alcohol group which wouldotherwise undergo a phase Il metabolic conjugation reactionleading to rapid excretion of the drug.The acetyl groups increase the stability of the drug in thecellular environment.O Il..

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Answered: The following structure is more active…

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The following structure is more active than morphine as an analgesic. H3C H. CH3 H3C´ O Il.. O Il..

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter27: Metabolic Integration And Organ Specialization

Section: Chapter Questions

Problem 5P

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Question

The following structure is more active than morphine as an
analgesic.
H3C
CH3
H.
H3C'
O Il..
What is the principal reason for this?
The extra acetyl group binds to cell surface receptors improving
active internalization.
The acetyl groups mask a polar group allowing the structure to
cross the blood brain barrier more efficiently.
The extra acetyl group masks an alcohol group which would
otherwise undergo a phase Il metabolic conjugation reaction
leading to rapid excretion of the drug.
The acetyl groups increase the stability of the drug in the
cellular environment.
O Il..

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