The gamma globulin of human blood serum exists in two forms, Gm(a+) and Gm(a-), specified respectively by an autosomal dominant gene Gm(a+) and its recessive allele Gm(a-). Broman et al. (1963) recorded the tabulated phenotypic frequencies in three Swedish populations. Assuming the populations were at Hardy-Weinberg equilibrium, calculate the frequency of heterozygotes in each population.

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 8.5P
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  1. The gamma globulin of human blood serum exists in two forms, Gm(a+) and Gm(a-), specified respectively by an autosomal dominant gene Gm(a+) and its recessive allele Gm(a-). Broman et al. (1963) recorded the tabulated phenotypic frequencies in three Swedish populations. Assuming the populations were at Hardy-Weinberg equilibrium, calculate the frequency of heterozygotes in each population.

 

Region
No. Tested
Phenotype %
Gm(a+)
Gm(a-)
Norbotten County
139
55.40
44.60
Stockholm city and
509
57.76
42.24
rural district
Malmohus and
293
54.95
45.05
Kristianstad counties
Transcribed Image Text:Region No. Tested Phenotype % Gm(a+) Gm(a-) Norbotten County 139 55.40 44.60 Stockholm city and 509 57.76 42.24 rural district Malmohus and 293 54.95 45.05 Kristianstad counties
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