The mouse and human genome have large syntenic blocks of genes in common Mouse chromosome 11 60 65 70 75 80 85 90 95 100 105 110 115 120 Ancestral chromosome o 15 20 25 55 60 10 30 35 40 45 50 65 70 Human chromosome 17 O 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 FIGURE 14-17 Synteny between human chromosome 17 and mouse chromosome 11. Large conserved syntenic blocks 100 kb or greater in size are shown in human chromosome 17, mouse chromosome 11, and the inferred chromosome of their last common ancestor (reconstructed by analysis of other mammalian genomes). Direct blocks of synteny are shown in light purple; inverted blocks are shown in green. Chromosome sizes are indicated in megabases (Mb). [Data from M. C. Zody et l., "DNA Sequence of Human Chromosome 17 and Analysis of Rearrangement in the Human Lineage," Nature 440, 2006, 1045–1049, Fig. 2.]
The mouse and human genome have large syntenic blocks of genes in common Mouse chromosome 11 60 65 70 75 80 85 90 95 100 105 110 115 120 Ancestral chromosome o 15 20 25 55 60 10 30 35 40 45 50 65 70 Human chromosome 17 O 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 FIGURE 14-17 Synteny between human chromosome 17 and mouse chromosome 11. Large conserved syntenic blocks 100 kb or greater in size are shown in human chromosome 17, mouse chromosome 11, and the inferred chromosome of their last common ancestor (reconstructed by analysis of other mammalian genomes). Direct blocks of synteny are shown in light purple; inverted blocks are shown in green. Chromosome sizes are indicated in megabases (Mb). [Data from M. C. Zody et l., "DNA Sequence of Human Chromosome 17 and Analysis of Rearrangement in the Human Lineage," Nature 440, 2006, 1045–1049, Fig. 2.]
Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Figure 14-17 shows syntenic regions of mouse chromosome 11 and human chromosome 17. What do these syntenic regions reveal about the genome of the last common ancestor of mice and humans?
![The mouse and human genome have large syntenic blocks of genes in common
Mouse
chromosome 11 60
65
70
75
80
85
90
95
100 105 110 115 120
Ancestral
chromosome o
15
20 25
55 60
10
30
35
40 45
50
65
70
Human
chromosome 17 O
5 10
15 20
25
30
35
40
45
50
55
60
65
70
75
FIGURE 14-17 Synteny between human chromosome 17 and mouse chromosome 11.
Large conserved syntenic blocks 100 kb or greater in size are shown in human chromosome
17, mouse chromosome 11, and the inferred chromosome of their last common ancestor
(reconstructed by analysis of other mammalian genomes). Direct blocks of synteny are
shown in light purple; inverted blocks are shown in green. Chromosome sizes are indicated
in megabases (Mb). [Data from M. C. Zody et l., "DNA Sequence of Human Chromosome 17 and
Analysis of Rearrangement in the Human Lineage," Nature 440, 2006, 1045–1049, Fig. 2.]](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fd6a2f2f1-7f3d-425f-8ff1-e7cab3e88757%2Fd3d1ea00-b86b-48d5-a2f3-7310c0f50e15%2F9958aln_processed.png&w=3840&q=75)
Transcribed Image Text:The mouse and human genome have large syntenic blocks of genes in common
Mouse
chromosome 11 60
65
70
75
80
85
90
95
100 105 110 115 120
Ancestral
chromosome o
15
20 25
55 60
10
30
35
40 45
50
65
70
Human
chromosome 17 O
5 10
15 20
25
30
35
40
45
50
55
60
65
70
75
FIGURE 14-17 Synteny between human chromosome 17 and mouse chromosome 11.
Large conserved syntenic blocks 100 kb or greater in size are shown in human chromosome
17, mouse chromosome 11, and the inferred chromosome of their last common ancestor
(reconstructed by analysis of other mammalian genomes). Direct blocks of synteny are
shown in light purple; inverted blocks are shown in green. Chromosome sizes are indicated
in megabases (Mb). [Data from M. C. Zody et l., "DNA Sequence of Human Chromosome 17 and
Analysis of Rearrangement in the Human Lineage," Nature 440, 2006, 1045–1049, Fig. 2.]
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