The protein hemoglobin (Hb) transports O2 in mammalian blood. Each Hb can bind 4 O2 molecules. The equilibrium constant for the O2 binding reaction is higher in fetal hemoglobin than in adult hemoglobin. In discussing protein oxygen-binding capacity, biochemists use a measure called the P50 value, defined as the partial pressure of oxygen at which 50% of the protein is saturated. Fetal hemoglobin has a P50 value of 19 torr, and adult hemoglobin has a P50 value of 26.8 torr. Use these data to estimate how much larger Kc is for the aqueous reaction 4O2(g) + Hb(aq) = [Hb(O2)4(aq)] in a fetus, compared to Kc for the same reaction in an adult.
The protein hemoglobin (Hb) transports O2 in mammalian blood. Each Hb can bind 4 O2 molecules. The equilibrium constant for the O2 binding reaction is higher in fetal hemoglobin than in adult hemoglobin. In discussing protein oxygen-binding capacity, biochemists use a measure called the P50 value, defined as the partial pressure of oxygen at which 50% of the protein is saturated. Fetal hemoglobin has a P50 value of 19 torr, and adult hemoglobin has a P50 value of 26.8 torr. Use these data to estimate how much larger Kc is for the aqueous reaction 4O2(g) + Hb(aq) = [Hb(O2)4(aq)] in a fetus, compared to Kc for the same reaction in an adult.
Physical Chemistry
2nd Edition
ISBN:9781133958437
Author:Ball, David W. (david Warren), BAER, Tomas
Publisher:Ball, David W. (david Warren), BAER, Tomas
Chapter5: Introduction To Chemical Equilibrium
Section: Chapter Questions
Problem 5.49E: 5.49. Consider the following equilibrium:
What is the effect on the equilibrium of each of the...
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The protein hemoglobin (Hb) transports O2 in mammalian blood. Each Hb can bind 4 O2 molecules. The equilibrium constant for the O2 binding reaction is higher in fetal hemoglobin than in adult hemoglobin. In discussing protein oxygen-binding capacity, biochemists use a measure called the P50 value, defined as the partial pressure of oxygen at which 50% of the protein is saturated. Fetal hemoglobin has a P50 value of 19 torr, and adult hemoglobin has a P50 value of 26.8 torr. Use these data to estimate how much larger Kc is for the aqueous reaction 4O2(g) + Hb(aq) = [Hb(O2)4(aq)] in a fetus, compared to Kc for the same reaction in an adult.
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