The reverse aldol condensation is at the heart of the preparatory phase of glycolysis. A) Why is this reaction needed for the effective harvest of energy from glucose? In other words, why does the cell change the length of the glucose chain from one 6-carbon chain to two 3-carbon chains? B) The reverse aldol reaction requires a specific set of molecular features to be catalyzed. In Class I aldolases, this feature is governed by the chemistry of an active site lysine sidechain. In Class II aldolases, this feature is governed by the chemistry of an active site Zn?+ cation. Why are these features important in promoting the reverse aldol cleavage of fructose 1,6-bisphosphate (shown)? Midterm CHOPO,2- Fo HO- -H H- -OH H- FHO- CH2OPO,2

The reverse aldol condensation is at the heart of the preparatory phase of glycolysis. A) Why is this reaction needed for the effective harvest of energy from glucose? In other words, why does the cell change the length of the glucose chain from one 6-carbon chain to two 3-carbon chains? B) The reverse aldol reaction requires a specific set of molecular features to be catalyzed. In Class I aldolases, this feature is governed by the chemistry of an active site lysine sidechain. In Class II aldolases, this feature is governed by the chemistry of an active site Zn?+ cation. Why are these features important in promoting the reverse aldol cleavage of fructose 1,6-bisphosphate (shown)? Midterm CHOPO,2- Fo HO- -H H- -OH H- FHO- CH2OPO,2

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter22: Carbonyl Alpha-substitution Reactions

Section22.SE: Something Extra

Problem 30MP: One of the later steps in glucose biosynthesis is the isomerization of fructose 6-phosphate to...

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During the second reaction of glycolysis, the carbonyl group is moved from carbon 1 to carbon 2 forming the ketose fructose-6-phosphate. This is a necessary step in glycolysis because O this is an energetically favorable reaction that drives the first step in glycolysis forward the carbonyl in this position stabilizes the subsequent formation of the enediol intermediate the position of the carbonyl will determine the cleavage point in the reverse aldol condensation two steps later this allows transfer of the phosphate group from fructose to ADP to form ATP in the next step
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