To get approved by the FDA generic drugs have to demonstrate the following: That their bio availability is the same as brand name drug That their bio equivalence is the same as the brand name drug That their bio availability AND bio equivalence is the same as the brand name drug None of the above
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- When pharmacology of the drug is required it must include the following • Description of the chemical class of the drugs, chemical equations or structure. The Mechanism of action of the drug which is usually the same for all drugs within the class. The pharmacokinetics, this will vary with the specific agent. So, design a table to capture the ADME and the uniqueness of the specific agent. • The side and adverse effects Interactions • Uses Regarding the physiology • Discuss the control of release of the endogenous substance Discuss the biosynthesis and metabolism of the substance • Mechanism of action The receptor types The physiological function of the substance through the specific receptors.Name the three basic classes of drug targets in medicinal chemistry and indicate, which are the most/least important as targets for biologics? I don't sure if I answer these questions correctly. Hope someone can give me confirmation and explain to me how enzymes will be affected by bioloigcs? My answer so far: The three common classes of drug targets are; receptors, nucleic acid, and enzymes. As a target for biologics, the least important will be a nucleic acid, and the most important will be receptor and second enzymes. Biologic drugs such as monoclonal antibodies will bind to the antigens, which are overexpressed receptor that need to be deactivated. In this case, the monoclonal antibodies will act as an antagonist and block the ligand from binding to the antigens, which are extensively presented in cancer cells. In addition, it can also affect enzymes by.......?As a pharmacist, propose some improvement that can be implemented to further improve the formulation stability. Answer this case study using your own words.
- Discuss the effects of glass packaging materials on pharmaceutical dosage form? Discuss at your own wordsYou want to prescribe an antacid to a patient at a dose of 10 mL at QDS for 28 days. Two brands are available: Brand A costs £4.20 per 300 mL bottle and Brand B costs £5.20 per 500 ml bottle. What is the most cost-effective option?Please explain in your own words your understanding of the NSQHS Medication Safety Standard. Please provide a detailed example from your clinical placements of this standard to your practice (the example must be presented using the STAR format).
- What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? This under Bipharmaceurics and Pharmacokinetics subjectDiscuss one of the practical advanced pharmaceutical analysis experiences (about its use in pharmaceutical analysis) إجابتك Discuss one of the practical advanced pharmaceutical analysis experiences (about its use in pharmaceutical analysis) إجابتكTime-release” drugs work by releasing a drug to the body at a constant rate such that the drug concentration at one time is not large enough as to cause harmful side effects OR not low enough to the point where it is an ineffective therapeutic. A design schematic of a time-release pill is shown below. Explain how it works from an osmotic pressure standpoint.
- From an economic point of view, the consultancy firm wanted to calculate the price a patient wouldneed to pay for the full treatment. The cost of each vial of the drug ‘A’ is $450.50 dollar where it contains 30 mg. The usual dose of drug administered is 145 mg once every 2 weeks, during a 12-week period to a patient weighing 190 lb and a height of 6 ft 2 inch. Calculate the cost for the full treatment for the above patient.What impact does compounding have in pharmacy? Describe how compounding can improve medication compliance.Select ready-made drugs in different dosage forms from the variety of drugs and classify them according to all classification signs (Annex 1). Write down the results into table 1. Ready-made drugs classification results No Name of ready- made drug By the By the By the applica-tion toxicity By physical By dates of By state of and chemical expira-tion aggregation and pharmaco- logical activity method properties dosage form Example Norfloxacine Antimicro-bial For internal General list Require light- Solid (tablets) Storage period is 3 agent use protection years 1 2 3 4 5 Classification