What happens if ATP is not available in the sliding filament theory? When is the maximum force generated and why/how? Why could it be beneficial for maximum force to be generated at that point?
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5) What happens if ATP is not available in the sliding filament theory? When is the maximum force generated and why/how? Why could it be beneficial for maximum force to be generated at that point?
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- What happens if ATP is not available in the sliding filament theory?1. Draw and label the steps of the sliding filament mechanism in skeletal muscle. This should be four parts (Cross- bridge, power stroke, disassociation, reactivation). On each part, be sure to include the following structures: actin, myosin, troponin, tropomyosin. Also include ATP, myosin ATPase, ADP, Pi, and H* (where important). • Cross-bridge: . Powerstroke: ● Disassociation: ● Reactivation:Outline the role of calcium ions on muscle contraction during a biceps curl. In your answer: A) Describe the role of the nervous system in stimulating the release of calcium ions. b) Outline the role calcium ions play in the 'sliding filament theory?'
- The ability of myosin to walk along an actin filament may be observed with the aid of an appropriately equipped microscope. Describe how such assays are typically performed. Why is ATP required in these assays? How can such assays be used to determine the direction of myosin movement or the force produced by myosin?The sliding filament model of contraction is a theory that is used to explain how muscles contract to cause movement. The theory explains that the change in the length of the muscle during contraction is due to the sliding of the myofilaments past each other and not to a change in the length of either of the myofilaments.Name the stages of sliding filaments in order. Briefly explain each.
- Why does muscle fatigue occur? since sarcomeres within skeletal muscles are rigidly aligned with each other what do you think excessive stretch or compression (remember the basic structure of the sarcomere with overlapping thin and thick filaments and the length-tension relationship) will do to the force generation of a muscle contraction?3.4. About human skeletal muscle contraction, what are the correct statements? PHYSIOLOGY_basic (OJO) A muscle fiber is made by the parallel apposition of sarcomers. Generation of force relies on the formation of cross-bridges between actin and myosin filaments. In the process of contraction, adenosine triphosphate (ATP) is required both to drive the actin-myosin association-dissociation cycle and to recycle calcium back to the endoplasmic reticulum. Each muscle fiber is innervated by one neuron only. T tubules are plasma membrane invaginations of the sarcolemma that allow excitation-contraction coupling.For the skeletal muscle, hydrolyzation of ATP: Group of answer choices At the myosin head gives rise to the generation of power stroke. At the actin G-molecule gives rise to the generation of power stroke. At the myosin head give rise to the rotation of myosin head to the "cocked back" position. At the actin G-molecule give rise to the rotation of myosin head to the "cocked back" position.
- 2) Paula is a scientist who is developing a drug called Fremtol that will be used to treat muscle spasms. This drug acts on specific skeletal muscles to (1) block the release of Ca2+ ions from the sarcoplasmic reticulum, (2) inhibit the pivoting ability of the myosin heads of the thick filaments, and (3) block the production of ATP by the mitochondria in skeletal muscles. By using this drug, contraction of certain skeletal muscle fibers is reduced, which keeps those muscles from producing spasms. In the above scenario, Fremtol’s effect of blocking the release of Ca2+ ions from the sarcoplasmic reticulum would most directly prevent which the following? a. activation of tropomyosin b. activation of troponin c. activation of actin d. All of the above e. None of the above3) Paula is a scientist who is developing a drug called Fremtol that will be used to treat muscle spasms. This drug acts on specific skeletal muscles to (1) block the release of Ca2+ ions from the sarcoplasmic reticulum, (2) inhibit the pivoting ability of the myosin heads of the thick filaments, and (3) block the production of ATP by the mitochondria in skeletal muscles. By using this drug, contraction of certain skeletal muscle fibers is reduced, which keeps those muscles from producing spasms. In the above scenario, Fremtol’s effect of blocking muscle mitochondrial ATP production would result in the inability of the muscle to make ATP from ___________. a. creatine phosphate b. anaerobic glycolysis c. aerobic respiration d. All of the above e. None of the aboveDuring muscle contraction, some energy is supplied from creatine phosphate. Which of the following events occurs during the breakdown of creatine phosphate? Question 6 options: a ATP molecules breakdown producing ADP + P groups. b ATP molecules are formed when P groups are bonded to ADP. c ADP molecules break down producing AMP + P groups. d ADP molecules are formed when P groups are bonded to AMP