What is mutation? Distinguish between neutral and silent mutations; germ-line and utations; trisomy 21 and trisomy X: paracentric and nericentric inversion.

Q: How Mutations in differentgenes cause the same disease?

A: The permanent change in the sequence of nucleotides of the genome in an organism is called a…

Q: Why are chromosomal aberrations considered to have less significance than gene mutations for…

A: Chromosomal aberration refers to the alterations in a number of chromosomes such as loss or gain of…

Q: What are the chances of occurrence of hypermorphic mutation?

A: Mutations are defined as the permanent change in the DNA’s base sequence. The mutation that…

Q: What is the proper route for gene delivery in different kinds of disorders?

A: Gene therapy is a promising method for correcting host pathology by the manipulation of DNA…

Q: Which types of chromosome mutations Q.change the position of DNA sequences in a single chromosome…

A: When the mutation takes place in chromosomes, it is known as chromosomal mutation. There are four…

Q: What are the effects of duplication mutation?

A: Mutations are the alterations or the changes that occur in the DNA. Mutagens are the agents that are…

Q: Several Types of Genetic Variants Occur?

A: Genetic variation is phenomenon of change in the DNA sequence of genome in a constraint individual…

Q: What is the long term and short term effects of mutation on coding and non-coding DNA, the amount of…

A: A mutation is a change in the nucleotide sequence of an organism's genome, virus, or…

Q: What are the chances of occurrence of neomorphic mutation?

A: Neomorphic mutations are rare dominant gain-of-function mutations that produce a novel phenotype.

Q: How does mutation can affect the central dogma and the phenotype?

A: Mutations are the changes in the DNA sequence. The changes can be single base changes or a fragment…

Q: What is a mutation? How does a mutation lead to an altered phenotype? Describe two specific types of…

A: The cell is the basic structural and functional unit of the body. A cell is composed of various cell…

Q: Explain why loss-of-function mutations are frequently recessive, whereas gain-of-function mutations…

A: Mutation is an altered DNA sequence, which leads to changed gene product. Mutations are random and…

Q: What is Prenatal genetic diagnosis ?

A: Prenatal diagnosis involves non-invasive and invasive techniques. The non-invasive technique…

Q: What causes monosomy and trisomy disorders? deletion insertion translocation O non-disjunction

A: Monosomy and trisomy-  Monosomy = It is the type of aneuploidy when only one chromosome of a pair is…

Q: Why do gene mutations not result in chromosomal mutations?

A: Answer: Introduction: Mutation- These are the random heritable changes that occurs in the DNA…

Q: What are Categories of Genetic Variants?

A: The difference in DNA sequence between organisms of a population is called genetic variation. These…

Q: What is the effect of inversion mutation?

A: Mutation is a change in the sequence of genetic material either due to the mistake in replication or…

Q: Which of the following are associated with dynamic mutations? O Genomic imprinting O Trinucleotide…

A: First of all we will discuss that, what is dynamic mutation and its causes.  Dynamic mutation is the…

Q: In Cystic Fibrosis: How is the gene/chromosome affected? How is the cell, tissue, and body systems…

A: Cystic fibrosis is an innate sickness that influences the lungs and stomach related framework. The…

Q: How would you relate the cancer cellular pathophysiology with genomic instability?

A: Introduction  Cancer is well known disease now a day. In US, 1 in 2 women and 1 in 3 men develops…

Q: What is the most common symptom in a genetic disorder and why? Do all people exhibit this symptom of…

A: Genetic disorder is a health problem that had resulted due to one or more abnormalities of a person'…

Q: A rare class of dominant gain-of-function _______ arisesfrom neomorphic mutations that generate a…

A: Genes are the hereditary unit of the DNA that when expressed display a certain phenotype. A…

Q: In terms of chromosome mutations, what are the significance of monosomy/trisomy, auto/allo…

A: MutationMutation is a sudden change that occurs in DNA or gene due to mistake during DNA is copied…

Q: What is the phenotype associated with zygotic gene mutations?

A: ZYGOTE:- The male gamete "sperm" fuses with the female gamete "Ovum" and after this fusion "Zygote"…

Q: physical appearances of individuals affected by the abnormality structure of deletion, inversion,…

A: The phenotypes of individuals are effected by numerous factors. As much as it depends on factors…

Q: What are the chances of occurrence of antimorphic mutation?

A: Mutation is defined as sudden inheritable change that occurs usually in the DNA sequence.  Mutation…

Q: How do mutations affect genotype and phenotype?

A: The term mutation is defined as any type of change in deoxyribonucleic acid (DNA). It can be caused…

Q: How are genetic variants identified?

A:

Q: Are de novo mutations passed on?How many de novo gene mutations does the average person have?

A: De novo mutation is a genetic alteration that is present for the first time in a family member. It…

Q: Give Examples of oncogenic mutations?

A: An oncogene is a gene that has the potential to cause cancer when these genes are mutated or…

Q: Give the examples of Human Disorders Caused by Single-Gene Mutations ?

A: A single gene disorder is caused by mutations in the DNA sequence of a specific gene or at an…

Q: Why is the incidence of survivable genetic disorders involving deletions of parts of chromosomes so…

A: Deletion is a type of mutation in which a part of DNA molecule is not copied during DNA replication.…

Q: What are Possible Dominance Relations in case of neomorphic mutations?

A: Any permanent change in the DNA’s nucleotide sequence is termed as mutations. Based on their effect…

Q: What is a A germline mutation?

A: A germinal mutation or germline mutation as the word indicates itself it is a mutation in germline…

Q: List the three basic categories of chromosome mutations and define each one.

A: Aneuploidy refers to a condition of an abnormal or unusual number of chromosomes. Normally each…

Q: Explain the Categories of Genetic Variants?

A: Genetics is the study of how traits are passed from one generation to another. This includes but is…

Q: What are the chances of occurrence of hypomorphic mutation?

A: Mutation is defined as the sudden inheritable change that occurs in the DNA sequence.  It is caused…

Q: Describe how different types of chromosomalrearrangements alter gene expression patterns orgenerate…

A: Chromosomal rearrangement is a that is mutation caused by a breakage in the deoxyribonucleic acid…

Q: Explain maternal-effect mutations?

A: Mutation means sudden changes occur in DNA sequences. The mutation occurs randomly. It also occurs…

Q: What are the causes affecting by genetic disorders?

A: BASIC INFORMATION GENETIC DISORDER It is the disorder which are inherited from one generation to…

Q: Explain the mechanisms of disease development that result from or cause geneexpression changes in…

A: Mutations Changes to an organism's DNA sequence .  Can be the result of viral infection, exposure…

Q: Define deletion?

A: Chromosomes are thread-like structures situated inside the nucleus of plant and animal cells. Each…

Q: When Replacement of the original gene occurs ?

A: A gene is the essential physical and functional unit of heredity. They are comprised of DNA…

Q: Compare and contrast the molecular mechanisms leading to FX syndrome and to FSHMD.

A: Introduction :- A gene originally known as FMR1 gene by scientists and responsible for FXS is…

Q: To play Jeopardy, the answer is given. You must supply the questie best question for the following…

A: While mendelian genetics helps us understand the inheritance of normal genes there are certain…

Q: What is mutation? Distinguish between (i) neutral and silent mutation (ii) germ line and somatic…

A: Mutations can sometimes be beneficial, when they result in traits that will benefit the organism.…

Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.