What is the simplest explanation for why patients have been identified with only one copy of the phosphofructokinase-1 gene (heterozygous), but no patients have been identified that lack both copies of the phosphofructokinase-1 gene (homozygous)? Patients lacking both copies of the phosphofructokinase-1 genes will be found once DNA sequencing technology can sequence whole genomes. Phosphofructokinase-1 is needed for nitrogen metabolism and there are no enzymes to replace this function, so cells die from ammonia toxicity. O Phosphofructokinase-1 is a required enzyme for carbohydrate metabolism in all living cells, complete loss of this enzyme would be lethal. There are 6 phosphofructokinase-1 paralogous genes in humans and it is impossible to lack both type 1 copies when there are also types 4, 5, and 6.
What is the simplest explanation for why patients have been identified with only one copy of the phosphofructokinase-1 gene (heterozygous), but no patients have been identified that lack both copies of the phosphofructokinase-1 gene (homozygous)? Patients lacking both copies of the phosphofructokinase-1 genes will be found once DNA sequencing technology can sequence whole genomes. Phosphofructokinase-1 is needed for nitrogen metabolism and there are no enzymes to replace this function, so cells die from ammonia toxicity. O Phosphofructokinase-1 is a required enzyme for carbohydrate metabolism in all living cells, complete loss of this enzyme would be lethal. There are 6 phosphofructokinase-1 paralogous genes in humans and it is impossible to lack both type 1 copies when there are also types 4, 5, and 6.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Genetic Recombination
Recombination is crucial to this process because it allows genes to be reassorted into diverse combinations. Genetic recombination is the process of combining genetic components from two different origins into a single unit. In prokaryotes, genetic recombination takes place by the unilateral transfer of deoxyribonucleic acid. It includes transduction, transformation, and conjugation. The genetic exchange occurring between homologous deoxyribonucleic acid sequences (DNA) from two different sources is termed general recombination. For this to happen, an identical sequence of the two recombining molecules is required. The process of genetic exchange which occurs in eukaryotes during sexual reproduction such as meiosis is an example of this type of genetic recombination.
Microbial Genetics
Genes are the functional units of heredity. They transfer characteristic information from parents to the offspring.
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Transcribed Image Text:What is the simplest explanation for why patients have been identified with
only one copy of the phosphofructokinase-1 gene (heterozygous), but no
patients have been identified that lack both copies of the
phosphofructokinase-1 gene (homozygous)?
Patients lacking both copies of the phosphofructokinase-1 genes will be
found once DNA sequencing technology can sequence whole genomes.
Phosphofructokinase-1 is needed for nitrogen metabolism and there are
no enzymes to replace this function, so cells die from ammonia toxicity.
Phosphofructokinase-1 is a required enzyme for carbohydrate
metabolism in all living cells, complete loss of this enzyme would be
lethal.
There are 6 phosphofructokinase-1 paralogous genes in humans and it is
impossible to lack both type 1 copies when there are also types 4, 5, and
6.
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