What statement is true regarding the retinal pigment epithelium? Cells in the PE are the site of phototransduction Cells in the PE signal between rods and bipolar cells Cells in the PE have enzymes that convert the light-sensitive photopigments back to a useable form Cells in the PE send their axons out of the retina
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- How are Ca2+ channels involved in phototransduction? they cause neurotransmitter release even if no action potentials are produced are not affected by PDE activation in the outer segments when open, they lead to hyperpolarization in photoreceptors in darkness, they do not rely on CGMP levels The density of cones in the retina: is highest where cone outer segments increase in diameter is lowest where retinal blood vessels are absent is drastically less than that of rods in the fovea is indicative of what areas are associated with acuity The recycling of rhodopsin.Photoreceptors in the retina have special channels that are open to Na+ in the dark. When light hits photoreceptors, these special channels close. What can you cònclude from this? None of the above O Photoreceptors hyperpolarize to light Photoreceptors depolarize to light Photoreceptor voltage does not change in the presence of lightkey function of rod photoreceptors is to: detect colors detect fine details in the visual field. detect light under low levels of illumination. detect light under high levels of illumination. During phototransduction, transducin activates phosphodiesterase (PDE) that converts: GTP to GDP CGMP to GMP retinal cis to retinal trans retinal trans to retinal cis
- Retinal is therefore a key player that triggers a series of activation in phototransduction (see figure below). Phototransduction in photoreceptor cells Disc membrane 1000000000…………………………. Disc lumen Light Rhodopsin GDP Transducin Photoreceptor cytosol GTP GTP GTP PDE CGMP CGMP inhibition CGMP GMP PDE6i GMP GMP Extracellular environment Plasma membrane 1. Light hits the retinal molecule and changes into an all-trans configuration 2. This change in the retinal conformation activates the rhodopsin photoreceptor 3. The rhodopsin photoreceptor then activates a specific heterotrimeric G protein called transducin. 4. The transducin then activates a downstream protein called PDE. Both PDE and the transducin G protein are attached to the plasma membrane by a lipid anchor. This makes them close to each other and facilitates the activation of PDE by the transducin G protein. The activity of the protein PDE can itself be regulated. It can for example be inhibited by a drug called PDE6i. 7. What…which of the following is NOT a step in rod phototransduction by rhodopsin? activation of rhodopsin by photons conversion of cGMP to GMP by phosphodiesterase opening of cGMP-dependent ion channels and hyperpolarization of the membrane activation of phosphodiesterase by light-activated rhodopsin through Galphat, (couldn't add the alpha into that part i didn't select an answer resulting in getting it wrong and wish to know what the correct answer is and how it is the correct answerPlace the following into the correct order to represent the bleaching and regeneration of rhodopsin. Opsin and cis-retinal enzymatically combine to regenerate rhodopsin Trans-retinal is enzymatically converted back to cis-retinal Cis-retinal isomerizes to trans-retinal Trans-retinal separates from opsin Opsin triggers reaction cascade that breaks down cGMP Rhodopsin absorbs photon of light www Next >
- The membrane potential of cells within the visual system is recorded in the dark, then following a brief flash of light. During the flash of light you would expect __________ cells to _____________ a rod cell; hyperpolarize b bipolar cell; depolarize c ganglion cell; depolarize d all of the above are correctThe recycling of rhodopsin: involves quanylate cyclase but not arrestin all of the answers are correct takes place exclusively in the outer segment limits the enormous signal amplification of phototransduction The fovea centralis, the center of the fovea, is responsible for: Glaucoma Accommodation Blindness acute vision O OODescribe the steps involved in vertebrate phototransduction by photoreceptors and further retinal processing by bipolar and ganglion cells.
- The best characterization of receptive fields in retinal ganglion cells that respond best to light-dark contrast is that for a cell that responds to light it has no response to light in its center on field for a cell that responds to light it has a strong response to light in the surround field for a cell that responds to light it has a strong response to light in its center on field for a cell that responds to light it has a weak response to light in its center on fieldCaffeine is an inhibitor of the enzyme phosphodiesterase. Predict what caffeine will do to my heart rate -- Support with the correct physiological mechanism And you may ask yourself "Well....how did I get to membrane potentials?" If caffeine were applied to the retina, what would happen. Include the mechanism we covered on how you detect lightWhich the correct order of passing information of light stimuli among cells in the retina? ganglion cell → bipolar cells → photoreceptor photoreceptor → amacrine cells → ganglion cell horizontal cell photoreceptor →ganglion cell Ophotoreceptor → bipolar cells → ganglion cell