Which synthetic sequence will give the following overall transformation? how? (1) LDA / THF; (2) CH31; (3) H2 / Pd on C a. H2 / Pd on C b. (1) HBr; (2) CH3LI; (3) H2 / Pd on C C. (1) BH3 / THF; (2) H2O2: (3) CH3LI d. (1) Li / NH3(iq): (2) CH3I Oe.
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- What reagents are necessary to carry out the conversion shown? OH CH₂CH3 CH₂CH3 O Na₂Cr₂O7/H2SO4/H₂O; CH3CH₂CH₂CH₂MgBr; H₂O O Na2Cr₂O7/H2SO4/H2O; SOCI2; excess CH3CH₂CH₂CuLi; H₂O O Na₂Cr₂O7/H₂SO4; excess CH3CH₂MgBr; H3O+ O Na₂Cr₂O7/H₂SO4/H₂O; SOCI₂; excess CH3CH₂MgBr; H₂O O Na₂Cr₂O7; SOCI2; CH3CH₂MgBr; H₂OWhat is an appropriate stepwise synthesis for the conversion shown? a-do O PBr3; PCC; H₂O O PBr3; H₂SO4; PCC; H₂O O KMnO4; CrO3; H₂O O KMnO4/NaOH/H₂O (hot); H₂O O KMnO4/NaOH/H₂O (cold); CrO3/H₂SO4/H₂O -OH OWhich synthetic route(s) would complete the reaction shown? Br || ||| I and II O I and III ? HO OH + enantiomer Synthesis I: 1. NaCCCH3; 2. Na/NH3(I) ;3. OsO4; 4. NaHSO3, H₂O Synthesis II: 2. NaCCCH3; 2. H2, Lindlar's catalyst; 3. MCPBA; 4. aq. H₂SO4 Synthesis III: 1. NaCCCH3; 2. H₂, Pt; 3. MCPBA; 4. aq. H₂SO4
- 6) Give the structures of the compounds A-E in the synthetic sequences below. PBr3, Br2 NH3, excess LOH A B you 1) NaNH2 (1 equiv) H2O, HgSO4 Br2 excess HCECH C D E H2SO4 NaOH excess 2) BuCI (1 equiv)Identify the reagents necessary for all three methods. ? OH ajay O CH3CH₂ONa ? ? 1) NaOH; 2) CH3CH₂OH CH3CH₂OH, H₂SO4 1) NaOH; 2) CH3CH₂Br OCH3CH₂Br, H₂SO4 □1) SOCI₂; 2) CH3CH₂OH, pyridine OEtProvide the reagents necessary to carry out the conversion shown. 1. H2O; 2. KMnO4 1. O3; 2. DMS; 3. Na2Cr2O7/H2SO4/H2O 1. NaOH, Br2; 2. DMS; 3. H2O/heat 1. O3; 2. DMS; 3. KMnO4 1. DMS; 2. H2O2/heat
- Show a possible mechanism for the following reaction 1) EtMgBr (еxcess) 2) H20 Et OH Me •Me "Et w..This is a multi-step synthesis problem. What reagents are need to carry out the shown chemical transformation ? OH 1.) SOCI2; 2.) D20 3.) NaBD4 O1. 1.) PBr3; 2.) LDA; 3.) BD3 and D202 2. 1.) PBr3; 2.) CuBr; 3.) D20 3. 1.) Tos-Cl; 2.) LiBr; 3.) D20 O4. 1.) SOCI2; 2.) Mg; 3.) D20 5.Which reagents can be used to achieve synthesis of the indicated target molecule? Conc. KMNO4/ H* / acetone 1) O3/ Zn/H* 2) PCC/CH2Cl2 O 1) Conc. KMNO4 /H* 2) LIAIH4/THF 4) H3O* 1) Conc. KMNO4, 2) HBr, 3) Mg/ether, 4) CO2 O3/ Zn/H*
- Choose the correct reagents and reaction sequence for the following transformation. ? CH3 Br CH3 -СООН O A. (1) HCN; (2) KOH/H2O, D; (3) H*/H2O O B. (1) Mg/ether; (2) acetone; (3) CrO3/H2SO4, D O C. (1) NaCN, D; (2) NaOH/H2O, D; (3) H*/H2O O D.(1) Mg/ether; (2) CO2; (3) H*/H2034. Select the best synthetic sequence to accomplish the transformation shown. Br A. 1. NaOEt; 2. HBr, cold, dark; 3. H₂SO4, H₂O B. 1. NaOEt; 2. HBr hv, A; 3. KO/Bu C. 1. NaOEt; 2. HBr cold, dark; 3. KOtBu D. 1. NaOEt; 2. Br₂; 3. KOBU E. 1. NaOEt; 2. Br₂, hv 35. In the retrosynthesis shown below: which compound could be converted to the alkyne shown in a single reaction step, with the appropriate reagents? Br -Bri Br Br || ||| IV B. C. D. E. None 36. In the retrosynthesis shown below: which compound(s) could lead to the alcohol shown in a single step, with the appropriate reagents? OH IV I B. 11 C. ||| D. E. A. I & II 37. Which alkene cannot be converted into an alkyne by reacting it with 1) bromine followed by 2) an excess of sodium amide and then 3) water? || IV B. C. E. All work D. BrWhich method would work the best in accomplishing the following transformation? CEC- Multiple Choice ) Br2. [2] 2eq. NaNH2 HBr. [2] 2eq. NaNH2 IMBH3. THF: (2) H202. NAOH; (3] NaNH2 (1) Br2, H20. [2) NaNH2