Two of the most outstanding secondary metabolites in Mexican oregano are the isomers carvacrol and thymol (FIG.3) (76). Since the two are isomers, it is no surprise that both compounds have similar properties such as: anti-inflammatory, anti-oxidant, and anti-fungal (76). Carvacrol is a thick, either colorless or yellow liquid (77). Its IUPAC name is 2-methyl-5-propan-2-ylphenol and the molecular weight is 150.2 g/mol (77).
Thymol is a large colorless crystal (78). Its IUPAC name is 5-methyl-2-propan-2-ylphenol and molecular weight is 150.2 g/mol (78). Thymol is a substituted phenol that is acquired from thyme oil or another unstable oil (78-79). Thymol is used in a variety of industries including: cosmetic, agriculture, medical, and food
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Another experiment was performed in Turkey to understand carvacrol’s possible shielding function in Type 1 diabetes (83). The researchers’ performed an in vivo experiment utilizing rats induced with Type 1 diabetes by streptozotocin to examine the defending role of carvacrol. The carvacrol used in this study was obtained from essential oil of Origanum onites L., steam distilled and isolated using the fractional distillation method. The researchers found a reduction in serum glucose level, serum total cholesterol, and other enzymes in carvacrol-treated rats in comparison to the control rats. The authors of the study concluded that orogastric addition of carvacrol to the diet of diabetic rats may have a moderate defensive role on enzymes found in the liver (83).
Thymol, another compound found in Mexican oregano, is being researched (especially using thyme essential oil; note that thymol is a compound found in numerous plant species). In a study conducted with male albino rats, the researchers investigated the effect of raw thyme oil (along with other raw oils such as fenugreek, sesame, cod liver, and hazelnut) on serum glucose level and liver and kidney function (84). The researchers found that thyme, fenugreek, organic olive, and cod liver oils effectively prevented the side effects of diabetes on liver function. On the other hand, thyme oil, along with the other
According to data, the natural antibiotics worked better for defending against Bacillus cereus. The Oregano Oil and the Garlic had tied for first and proved to have the largest zone with a length of 18 millimeters between the disc and the bacteria after 48 hours of growth. For a bacteria such as “Food Poisoning” the final result was shocking that the least amount of growth was for the man made antibiotics because they were specifically made to fight these types of Bacteria. The final result for Gentamicin had proved it to have a much smaller zone of inhibition with a zone of just 12 milimeters after the 48 hour time period. The growth of the penicillin was the lowest of them all with the very small zone of 0 millimeters after the 48 hours.
Catechin has been shown to modulate the hepatic microsomal phospholipase A2 activities. It can change the hepatic phospholipid species in streptozotocin-induced diabetic rats [78]. On the other hand epigallocatechin gallate, a constituent of green tea, represses the hepatic glucose production. EGCG also mimics insulin by increasing phosphoinositide 3-kinase, mitogen-activated protein kinase. Furthermore, EGCG has been shown to regulate genes that encode gluconeogenic enzymes and protein-tyrosine phosphorylation by modulating the redox state of the cell. These finding suggest that EGCG, or derivatives can perform as antidiabetic agent [79]. Green tea has also been shown in vivo to down regulate the hepatic gluconeogenic gene-expressions of enzymes. The results of this study support the idea that green tea intake may be favorable in the prevention of diabetes mellitus [80]. Diabetes is multi-causal disease. Even the onset of the disease is caused by a single factor but its progression and pathogenesis may be attributed by a number of confounding factors. So, in some
This indicates that the metabolism of proteins was apparently affected by Ch.t extract. The improvement on the levels of protein and albumin in the diabetic treated groups show that Ch.t extract have significant effect in glucose and protein level because insulin inhibit gluconeogenesis from protein [ ] or could be due to improvement in renal function. This affirmative agrees with the fact that the weight of skeletal muscles was significantly increase in diabetic rats treated with Ch.t extract. The decrease in albumin level documented for diabetic rats may be due to liver massive necrosis, deterioration of liver function, hepatic resistance to insulin and glycogen impairment of oxidative phosphorylation[ ].Under the same experimental conditions serum globulin level revealed an appreciable decrease[ ]. The renal pathogenesis is related to duration of diabetes, the most devastating complication with diabetes is nephropathy[
Many people find thyme useful and effective when it comes to heal and treat many diseases. Thyme is a member of the most common herbs in the Labiatae (Mint) plant family, which have been used for centuries. In addition to that, there are about 350 species of thyme with a vast range of uses not only in natural medicine but also in pharmaceutical drugs. Thyme leaves are not the only part that have been used. In fact, oil extract from thyme leaves and its flowers also serves important roles in treating and curing many disorders.
The purpose of this lab was to isolate the cove oil from ground cloves and determine the identity of the major constituent that is known to have the molecular formula C10H12O2 through IR spectrometry.
Diabetes is a common health condition among many Americans today. As of 2014, 29.1 million people or 9.3 percent of the American population have diabetes and 86 million, or one out of three, Americans have pre-diabetes which increases one's risk for developing diabetes1. Since diabetes is a top health concern for a great number of Americans, many are open to integrative practices including dietary supplementation. With half of the American population using at least one dietary supplement and as an increasing number of Americans look to integrative medicine2, it is no surprise many opt for dietary supplements to aid in diabetes management. Cinnamon is a common household spice used in many culinary preparations and can be found as a dietary
Beta- carotene is an organic compound categorized as a terpenoid (Gutiérrez, & Gonzalez, 2010). Naturally, it is a predecessor of vitamin A, and found in several yellow fruits and vegetables. These organic nutrients play a vital role in aiding vision, skin growth, and bone development. In addition to these crucial roles, Beta-carotene may be of significant help in regulating the blood sugar in diabetic persons (Gutiérrez, & Gonzalez, 2010). Human bodies regulate blood sugar levels with the help of the hormone called insulin. In the absence or inadequate supply of this hormone, an individual is said to be diabetic. Diabetes may results in solemn conditions such as blindness, heart diseases, and stroke. Over the years, medical
Insulin resistance can also be caused by increased triglycerides and free fatty acids intake. This is due to the effect Triglycerides and free fatty acids have on insulin stimulated signal pathways, translocation protein-4 and glucose uptake (Choi, Jung, Park, & Song, 2004). It is found that CLA has a regulatory effect on glucose and lipid metabolism regulators. CLA affects the PPAR-y ligand, a major receptor that influences the expression and transcription of genes that are related to the metabolic effects of glucose and lipids. Such protein regulators as aP2, insulin-dependent glucose transporter 4, FATp, ACS and adiponectin are all influenced by increased CLA. (Xiao-Rong Zhoua, Chang-Hao Suna, Jia-Ren Liua, b, Dan Zhaoa, 2008). It was also theorized that CLA may act on other glucose regulators such as phosphoenolpyruvate carboxylase, glucose-6-phosphate, glucokinase, sterol-regulation element finding protein, acyl coenzyme A oxidase, fatty acid synthase and uncoupling protein. Testing done on rats with a mixture of cis 9, trans 11 and trans 10, cis 12 CLA had found that the only effected regulatory agents were regulators involved in gluconeogenesis such as Phosphoenol carboxykinase and transcriptional factors, sterol-regulating element binding protein-1c and PPAR-y (Choi, Jung, Park, & Song, 2004). The main regulatory effect on insulin resistance was the effect on ligand PPAR-y, a key regulator in lipid homeostasis. Mixtures of CLA isomers consisting of cis 9, trans 11 and trans 10,cis 12 effect gene expression of PPARy mRNA in rats. It was found to have affected the levels of aP2, FATP, ACS and adipoenectin mRNA expression in adipose tissue. CLA increased These regulatory proteins resulting in an uptake of free fatty acids into the adipose tissue and decreasing uptake into the muscle tissue. This has been found to improve muscle insulin
The three essential oils used in the trials were ginger, spearmint, and peppermint. All of the oils were extracted using steam distillation. In this meta-analysis, the results were inconclusive. Several studies found that there was no reliable evidence for the use of peppermint oil for the treatment of nausea. Conversely, there were studies that supported the efficacy of peppermint for reducing post-operative nausea. One randomized control trial ascertained that a blend of ginger, mints, and cardamom were effective in reducing nausea. Mint was found to reduce colonic spasms and slow peristalsis. Regarding the safety of essential oils, the possibility for reaction due to high concentration and lack of standardization resulting in the presence of differing substances poses potential risk for drug interaction or allergic response. In their review of available data, they found that there were 71 reported cases of adverse effects to aromatherapy, including one death. Topical application had the most adverse response with dermatitis being the primary reaction. With this in mind, it is important to spot test prior to liberal administration of topical essential
L., Moreno Luna, A. Y., Reed, R. L., Miranda, C. L., Bobe, G., Proteau, R. R., & Stevens, J. F., 2013). The highest dose group had a notably lower plasma glucose level in comparison to the control group, in males but not females and there was also a large decrease in body weight for male rats in the highest dose group; In comparison to the rats that received no xanthohumol, which was also not seen in female rats either (Legette, L. L., Moreno Luna, A. Y., Reed, R. L., Miranda, C. L., Bobe, G., Proteau, R. R., & Stevens, J. F., 2013). One interesting thing researchers learned was that the plasma cholesterol, insulin, triglycerides, MCP-1(monocyte chemoattractant protein-1), as well as food intake were not affected by treatment. These findings prove that xanthohumol has beneficial effects on markers of metabolic syndrome. This is useful because this means that it has been proven that researchers have answered their thesis and discovered that xanthohumol does have an effect on lowering body weight in obese male Zucker fa/fa rats. With this knowledge I believe that if we continue to experiment with xanthohumol as a potential drug, we would be able to eventually learn how to apply it to humans safely, in the hopes of creating a new efficient treatment alternative or even a cure for
Treated glycerol and commercial glycerol were analyzed using the Fourier Transform Infrared Spectrometry (FTIR) to determine the functional group. The functional group is a group of atoms that replace the hydrogen in the organic compound. The structure of organic family compounds and their properties are defined by organic compounds. Table 4.3 shows the comparison data for the glycerol residue, recovered glycerol and commercial glycerol.
The purpose of the experiment is isolate the natural products -terpenes and acetogenins- and to observe their properties. The terpene used was used to isolate was limonene from a citrus peel, and the acetogenin that was used to isolate was eugenol from clove oil. The techniques used to isolate these two natural products was a steam distillation and extraction. The amount of eugenol that was recovered 2.39 grams. After the recovery of eugenol, an IR spectrum was obtained. The IR spectrum displayed the presence of an alcohol at 3529.37 cm-1 and an alkene at 1638.08 cm-1. Classification tests are used to determine what is present.The results for the classification tests for eugenol are shown below in the table.
Eucalyptol is also known as 1,8-cineole (1,3,3-trimethyl-2-oxabicyclo[2,2,2]octane) is a monocyclic monoterpene ether (oxide) (figure 1) with an aromatic and camphor like odour found in essential oils of Eucalyptus globules, Eucalyptus polybractea (not less than 70% of Eucalyptol)1, Helichrysum gymnocephalum (47.4% Eucalyptol)2 ,Zingiber chrysanthum Rosc. (42% Eucalyptol) 3 and many other aromatic plants. Because of its pleasant spicy aroma and taste, eucalyptol is used in flavouring agent, fragrances, and cosmetics. Eucalyptol is listed in Code of Federal Regulation as Flavouring Agents and Related Substances 4. Eucalyptol has been considered as generally recognised as safe (GRAS)
-Authors stated that “A-ring” of flavonol in discussion part. But, in structure of the compound 1, ring(s) is/are not labelled as “A” ring. For better understanding, authors may label the ring.
Linalool is the main element found in many essentials oils. It is found in orange, lavender, rose, coriander and rosewood. In its pure form, Linalool has several anti-cancer properties and has found to be effective against leukemia as well as per the studies conducted.