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Mild Traumatic Brain Injury (TBI)

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Traumatic brain injury (TBI) is a worldwide health problem that can lead to death or long-term disability even in people with mild TBI, especially in young population (Menon et al., 2010). More than 1.3 million visits to emergency department in the United States report for TBI (Faul et al., 2010). TBI can lead to sundry impairments and disabilities in physical , functional, cognitive, emotional and social realms which remarkably reduce health-related quality of life(HRQL) (Scholten et al., 2015: Andelic et al., 2009). TBI can be classified according to it severity into mild-moderate and sever TBI. Mild TBI (MTBI) also termed concussion score for over 77% of the entire reported TBI cases in the United States. About 40% of these cases are frequently …show more content…

However it can be of limited use in mild traumatic brain injury diagnosis as the presence of multiple trauma, use of sedatives, physical stress and alcohol abuse (Practice Parameter: The management of concussion in sports (summary statement), 1997). Computed tomography (CT) scan and magnetic resonance imaging (MRI) are used to distinguish the degree of brain injury, yet in case of concussion CT and MRIs usually fail to declare injury lesions due to limited sensitivity. With the Improvement of technologies, MRIs have become more sensitive than CT but as their limited availability and great cost, the usage of this approach is hard to do for the acute stage of diagnosis and follow up (Bhomia et al., …show more content…

Different studies are now conducted to search for the role miRNA as a diagnostic biomarker in TBI (Sharma et al., 2014). Serum miRNAs are nearly stable at fluctuating pH conditions, resistant to enzymatic degradation and repeated freeze, that make them a acceptable biomarker applicant for MTBI17.A recent study has identified the expression of 10 up-regulated serum miRNAs including miR-486, miR-451, miR-328 and miR-92a in both MTBI and STBI (Bhomia et al., 2016). These findings may provide a new strategy for the early diagnostic, prognostic, and treatment of

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