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Orally Infused Tea

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As the cannabis is being orally administered infused in tea, the bioavailability of 4 to 20 per cent. A previous study has shown that the peak concentration of 20 mg of THC ranges from 4.4 to 11 ng/ml within 1 to 5 hours, depending on the individual (Huestis, 2009). This amount will provide an insufficient concentration to raise blood ghrelin levels, therefore, the orally infused tea of 5g cannabis must be consumed every 30 minutes for x amount of times to increase the blood ghrelin levels. The 11-hydroxy-THC metabolite will affect the brain at a faster and higher level compared to its parents compound. This compound elicits the central effects of THC orally and has a half-life of approximately 12 to 36 hours (Grotenhermen, 2003)

A clinical …show more content…

This circulating peptide hormone is mainly produced in the gastric mucosa, by the endocrine X/A-like cells (Lim et al., 2013). It is understood its orexigenic effects are controlled by the paraventricular nuclei (PVN) of the hypothalamus (Tucci et al., 2004). This specific hypothalamic site is a critical centre that is inhibited by ghrelin and involved in energy control and food intake (Kola et al., 2008). Ghrelin also increases the level of cannabinoids in the hypothalamus and is dependent on the cannabinoid 1 receptor (CB1)(Kola et al., 2008). Furthermore, the endocannabinoid system has demonstrated to play an important role in the orexigenic effects of ghrelin (Kola et al., …show more content…

This results in an increase in appetite and stimulation of catabolic activity, such as glycolysis (Lim et al., 2013). However, it causes a decline in AMPK activity in the liver and adipose tissue, which can lead to inhibition of anabolic processes, such as lipogenesis (Kola et al., 2005; Lim et al., 2013). AMPK also plays a key role in cellular energy homoeostasis in relation to the opposing effects of leptin and ghrelin in the hypothalamus (Kola et al., 2005). Moreover, the enzyme, AMPK, is involved in a major pathway associated with the regulation of appetite and metabolism (Kola et al.,

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