AP Biology Name Allison Werts Period 2
Chapter 19 guided Reading Assignment
1. What kind of nucleic acids are the viral genomes made of?
A singular linear or circular molecule.
2. What is the name for a protein shell enclosing the viral genome?
The name of the protein shell that encloses the viral genome is a capsid.
3. What are viral envelopes and what is their function?
They are membranes that cloak the capsid that in turn encloses a viral genome.
4. Define host range.
It is the limited range of host cells that each type of virus can infect and parasite.
5. List the full steps of the simplified viral reproductive cycle.
1.) Virus enters cell and is uncoated, releasing viral DNA and capsid proteins
2.) Host enzymes replicate the
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15. Describe the reproductive cycle of HIV, a retrovirus.
The virus fuses with the cell’s plasma membrane. The capsid proteins are removed, releasing the viral proteins and RNA. Reverse transcriptase catalyzes the synthesis of a DNA strand complementary to the viral RNA. Reverse transcriptase catalyzes the synthesis of a second DNA strand complementary to the first. The double-stranded DNA is incorporated as a provirus into the cell’s DNA. Proviral genes are transcribed into RNA molecules, which serve as genomes for the next viral generation and as mRNAs for translation into viral proteins. The viral proteins include capsid proteins and reverse transcriptase (made in the cytosol) and envelope glycoproteins (made in the ER). Vesicles transport the glycoproteins from the ER to the cell’s plasma membrane. Capsids are assembled around viral genomes and reverse transcriptase molecules. New viruses bud off from the host cell.
16. What are vaccines?
They are harmless variant or derivative of a pathogen that stimulates a host’s immune system to mount defenses against the pathogen
17. What are the three processes that contribute to the emergence of viral diseases?
The mutation of existing viruses, the spread of existing viruses from one host species to another, and the dissemination of a viral disease from a small, isolated population that can lead to widespread epidemics.
18. List and explain the two major routes
This religion was EMOTIONAL. They preached with fervor, with intensity, and it was a big change from the old, monotonous drones of preaching in tradition religion. It was important because it sparked a change in people, got them going again. They were losing their religion, and the Great Awakening was the jump-start they needed.
COMPANY BACKGROUND: EasyFind manufactures and sells golf balls. The company is conducting a price test to find a better price point. Presently their golf balls sell for $19 per dozen. Their current volume is 5,470 dozen per month. They are considering reducing their sales price by 20% per dozen.
Vaccination is the administration of antigenic material to stimulate an individual 's immune system to develop adaptive immunity to a pathogen. In simpler words, a vaccination is the injection of a killed or weakened organism that produces immunity in the body against that organism. The immune system is the body 's defense against
Viruses are microscopic particles that invade and take over both eukaryotic and prokaryotic cells. They consist of two structures, which are the nucleic acid and capsid. The nucleic acid contains all genetic material in the form of DNA or RNA, and is enclosed in the capsid, which is the protein coating that helps the virus attach to and penetrate the host cell. In some cases, certain viruses have a membrane surrounding the capsid, called an envelope. This structure allows viruses to become more stealthy and protected. There are two cycles in which a virus can go into: lytic and lysogenic. The lytic cycle consists of the virus attaching to a cell, injecting its DNA, and creating more viruses, which proceed to destroy the host. On the other hand, the lysogenic cycle includes the virus attaching to the cell, injecting its DNA, which combines with the cell’s DNA in order for it to become provirus. Then, the provirus DNA may eventually switch to the lytic cycle and destroy the host.
Viruses are microscopic organisms that can only replicate inside cells of the host organism. Viruses for the most part are so small you would have to use a conventional optical microscope. Viruses can infect any and all types of organisms, such as animals (to include Humans), plants and even bacteria as well as archaea (archaea constitutes a domain or kingdom of single-celled microorganisms). There are millions of different types of viruses. With viruses being believed to be the most abundant type of biological entity, they can be virtually found in every ecosystem on the planet.
- Vaccinations work with the body’s natural immune system in order to prevent future diseases and illnesses.
One of the most complex and unexplored disease causing agents are viruses. They are known to be able to infect a wide array of organisms, from plants and animals, to bacteria and fungi. Essentially, anything that is living is capable of being infected with a virus. Once the host's cell is infected, the viruses' goal is to produce more viruses which will infect neighboring cells to continue the cycle.
A virus is an infecting agent. Viruses are non-living they need a living host, a living organism to replicate themselves. When it invades a cell it will implant their code that is capable of copying itself. This will cause a detrimental effect, corrupting the system ti its advantage or complete destruction.
For example, viruses do not use energy and raw materials to grow and reproduce, and they are not made of one or more of the basic fundamental units of life – a cell. Compared to a cell, which includes organelles that enable the structure to grow and reproduce, a virus can only reproduce if another cell is present and that cell has organelles that the virus can inject its own DNA or RNA into and use it for its own replicating or mutating purposes. Viruses are made of a protein coat or capsid with its DNA or RNA genetic material enclosed inside of the capsid. In comparison, in addition to having organelles that use energy to help the cell develop, grow, and reproduce with the help of DNA, the cell by definition is enclosed in a membranous boundary,
Some viruses also have an outer bag of lipo-protein called an envelope. After a virus attaches to a living cell, it either enters the cell to release the genetic information, or, the virus injects the information through the cells outer lining. Thus changing the cells natural functions and forcing the cell to spend its energy to create copies of the virus. The cell will go on making copies of the virus until the cell is used up and dies. The virus then leaves the dead cell and invades a nearby cell and the process starts all over. There are five types of human herpes virus: Varicella zoster which causes chickenpox, Epstein Barr virus which causes infectious mononucleosis, cytomegalovirus which can cause cytomegalic inclusion disease in infants, and herpes simplex viruses 1 and 2.
A lot of the time when a virus come into contact with the host or as we may know it, the cell, it can insert its genetic material into its host, literally taking over the host's functions. Some viruses may remain dormant inside host cells for long periods, causing no obvious change in their host cells, but once stimulated new viruses are formed, self-assemble, and burst out of the host cell, killing the cell and going on to infect other cells. All this is just a constant battle between the host and cell. Without a host cell, viruses cannot carry out their life-sustaining functions or reproduce. They cannot synthesize proteins, because they lack ribosomes and must use the ribosomes of their host cells to translate viral messenger RNA into viral proteins. Viruses cannot generate or store energy, but have to derive their energy, and all other metabolic functions, from the host cell. Sometimes the virus will not be in the cell but outside functioning as coat for the protein. Viruses cause a number of diseases in humans most commonly heard of ones are, smallpox, the common cold, chickenpox, influenza, shingles, herpes, polio, rabies, ebola, hanta fever, and AIDS are examples of the diseases caused by viruses. Even some types of cancer but not all. As Sun Tzu wrote in The Art of War, “All warfare is based on deception”. He could have easily been describing the ancient battle between virus and host
Once tightly bound the virus is endocytosed via coated vesicles. The virus is transported into late endosomes which acidify their content and hence induce conformational rearrangement of HA exposing the fusiogenic peptide sequence. The loop region of the HA becomes a coiled coil that mediates membrane fusion. The release of viral genome into the cytoplasm also requires protons that are pumped from the acidic endosome into the virion interior via the matrix protein M2 that acts as a proton channel. Viral RNA dissociates from M1 and is then imported in an ATP-dependent manner into the nucleus for transcription and translation. In humans, the replication of the influenza virus is usually restricted to the airways epithelial cells due to the limited expression of a serine protease, produced by nonciliated bronchial epithelial cells and which cleaves the HA precursor in HA1 and HA2 polypeptides, rendering the virions infectious. Replication and virions production occurs within hours after virus entry. The viral ribonucleoprotein (vRNP) complexes are released from the endosomes into the cytoplasm and subsequently transported to the nucleus, where replication and transcription take
A vaccine or immunization is a dose administered by either injection, orally or sometimes nasally, of a living or killed microorganism. Vaccinations are given to produce or artificially increase immunity to a particular disease. The Centers for Disease Control (CDC) is an advocate fro pro vaccination. The CDC urges parents to have their children vaccinated. The CDC believes that vaccinations are an important step in keeping children safe from potentially dangerous diseases. According to the CDC vaccinations have significantly reduced and in some cases eliminated certain diseases. However, they warn that these diseases do still exist. The CDC admits that because of sucessfullness of vaccinations that most young parents have never seen the devastating effects that diseases such as polio, measles, or whooping cough ( also known as pertussis) can have on a family or community. “its easy to think of these as diseases that only existed in the past” says the CDC. The CDC warns that if the vaccination rates drop in a community that it would not be uncommon for an outbreak of such
The protective capsid helps the virus escape detection and destruction during the invasion of the host. When the virus reaches the target cell, biochemical reactions between the capsid and cell wall allow the virus to latch on and inject its genome into the cell’s interior. Once inside, the viral genetic material insinuates itself into the host’s DNA or RNA. In an efficient feat of natural bioengineering, the host cell’s genetic machinery now does the rest of the work for the virus. The cell, which had already been making copies of its own genome, now also replicates that of the virus. Coded within the viral material is the blueprint for making more copies of the viral genome. Further instructions command the production of capsids and directions for assembly of new viruses. After the host cell becomes engorged with viruses, it explodes, sending the new
The HIV-1 virion is approximately 120 nm in diameter, roughly spherical, and is composed of two copies of a single stranded positive sense RNA enclosed by a capsid (24). The HIV-1 genome is less than 10 kb and encodes for more than nine different gene products. It encodes for 3 major structural protein genes: gag (group-specific antigen), pol (DNA polymerase), and env (Envelope), which code for major structural proteins and essential enzymes. Gag generates the mature Gag protein matrix (MA or p17), capsid (CA or p24), nucleocapsid (NC or p7), and p6, which encompass proteins for the basic infrastructure of the virus such as the inner core of the viral particle (25). Pol encodes for reverse transcriptase (RT), which enables the virus to reproduce, integrase (IN), which is necessary to integrate the viral double stranded DNA into the host genome, RNAse H, and HIV protease, which are all encapsulated in the core of the inner particle formed by the viral capsid protein p24 (25). Env encodes for glycoproteins of the outer membrane such as outer gp120 (which enables the virus to attach and fuse to cells of the host), and transmembrane gp41 that anchors the glycoprotein complex to the surface of the virion (25). Between the core and the envelope is the HIV matrix proteins which are composed of the viral protein p17 (23). HIV-1 also encodes for proteins with important regulatory elements (tat (Trans-Activator of Transcription) and rev