Does Therapeutic Hypothermia Decrease Mortality in the Post Cardiac Arrest Patient?
In the United States out-of-hospital cardiac arrest (OHCA) is a common occurrence among adults. In 2013, according to the American Heart Association (AHA), 359,400 individuals suffered from OHCA with an overall survival rate of 9.5% (AHA, 2014). Even with rapid chain-of-survival initiation, (i.e. immediate recognition of cardiac arrest, early cardiopulmonary resuscitation (CPR), early defibrillation, effective advanced life support, and post cardiac care) mortality following OHCA remains elevated (Lee & Cone, 2014). In the chain of survival, the post resuscitation period is thought to be the missing link. Therapeutic hypothermia (TH) is one such post resuscitative
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He advocated that wounded soldiers be packed in snow and ice to improve outcomes following injury. Despite ancient beginnings, it was not until the early 1990s that researchers began to study the effects of TH in laboratory animals. In 1991 Sterz and colleagues (as cited in Lee & Asare, 2010), “demonstrated in a dog model that hypothermia induced after cardiac arrest was associated with significant improvements in neurologic outcomes” (p. 1229). In 2002, these early animal studies were supplemented by two simultaneously published landmark human studies. Both human studies were controlled and randomized. One of the studies took place in Europe and the other was conducted in Australia.
The European study followed 275 patients who suffered cardiac arrest due to VF. It compared the outcomes of patients being treated with mild hypothermia to standard normothermia (Holzer & Behringer, 2005). Patients in the hypothermia group were cooled to 32-34 °C over a median time of 105 minutes, and temperature was maintained for 24 hours (Lee & Asare, 2010). A favorable neurological outcome was seen in 55% of the hypothermia group compared to 39% of the normothermia group. Additionally, mortality in 6 months was 41% in the hypothermia group compared to 55% in the normothermia group (Lee & Asare,
Purpose: The purpose of this speech is to educate and inform my audience of the risks inherent from unintended hypothermia. I’m eager to alert perioperative staff of the potential dangers as well as the preventative measures that can be taken in order to avoid complications associated with unintended hypothermia. My central idea is hypothermia management saves lives.
He then took samples of urine, blood, and mucous as body temperatures lowered. Through this tortured, Rascher used the data to create the hypothermia treatment called "active rapid rewarming." More than 90 people lost their lives for this medical advancement (Adams).
THT is the only therapy that has appeared to positively affect the neurological outcome of patients after cardiac arrest. THT has been around for more than fifty years. The history of the scope of THT is limited and the only consistent application of this therapy invasive surgery. Within the last 10 years, the benefits of induced therapeutic hypothermia have been rediscovered, mainly with the improvement in neurological outcomes in out-of-hospital cardiac arrest (OOHCA) victims. In addition, therapeutic hypothermia has been suggested to improve outcome in other neurological conditions such as traumatic brain injury, neonatal asphyxia, cerebrovascular accidents and intracranial
The lack or delay in appropriate treatment for individuals who experience a sudden cardiac arrest has created a major public health disparity. Research into pre-hospital treatment and subsequent implementation has historically seen neglect by the medical and scientific community creating vast differences in survivability of cardiac arrests between demographic groups. In 2010, the American Heart Association and Emergency Cardiovascular Care program developed the 2020 impact goal to reduce death from cardiovascular disease and stroke by 20% and double out-of-hospital cardiac arrest (OHCA) survival rates (http://circ.ahajournals.org/content/121/4/586#sec-1). This has prompted a massive influx of research into the disparities that exist and an
The evidence surrounding the topic of therapeutic hypothermia post cardiac arrest is one lathered in potentially advantageous benefits, as well as harmful side effects. Although this procedure has potentially lifesaving and neurologically preserving implications, it does come with various side effects which can be dangerous in general or if left untreated. This paper will first address the many benefits, some of which include prolongation of life, retention of neurological function. It will then shed light upon some of the subsequent risks and harmful effects that are associated with therapeutic hypothermia. Lastly the paper will discuss why or why not the overall benefits outweigh the aggravating factors. Thus, being a topic of much controversy
Across all of the studies, hypothermia is effective in that ICP was decreased and CPP increased.
Hypothermia has two main types of causes. It classically occurs from exposure to extreme cold. Commonly this includes alcohol intoxication but may also include low blood sugar, anorexia, and advanced age. Hypothermia may be diagnosed based on either a person's symptoms in the presence of risk factors or by measuring a person's core temperature. One of the lowest documented body temperatures from which someone with accidental hypothermia has survived is in a near-drowning of a 7-year-old girl in Sweden. Survival after more than six hours of CPR has been described. Symptoms of mild hypothermia may be vague, Increased urine production due to cold, mental confusion, and hepatic dysfunction may also be present. Hyperglycemia may be present, as glucose consumption by cells and insulin secretion both decrease, and tissue sensitivity to insulin may be blunted. Sympathetic activation also releases glucose from the liver. In many cases, however, especially in alcoholic patients, hypoglycemia appears to be a more common presentation. Low body temperature results in shivering becoming more violent. Muscle mis-coordination becomes apparent. Movements are slow and labored, accompanied by a stumbling pace and mild confusion, although the person may appear alert. Surface blood
While numbers from the study may appear to show a positive improvement, the account of out-of-hospital neurological and physical deficits arising from the event are not shown throughout the study and need to be taken into consideration. The American Heart Association acknowledges the study and also acknowledges that there is not enough evidence to support they use or the lack of ACLS medications during a cardiac arrest.
David Casarett, there are many ways to preserve life after cardiac arrest. He says that all this research has led to most things used today that keep us alive longer. One of these things were Researchers at the University of Pittsburgh’s Safar Center chilling dogs at a very low temperature that helped keep them alive after cardiac arrest. He states that these studies have led to clinical trials that are designed to save patients who wouldn’t survive with conventional treatment.
Hypothermia protocol for the post cardiac arrest patient has been an evidence based practice of this therapy for about a decade now. This intervention, often used in the critical care setting, is now expanding to primary emergency responders as well. This paper will present some of the notable research that has been done on therapeutic hypothermia, and current use of this intervention.
Trauma, or unintentional (accidental) injuries, is the leading cause of death in individuals in the age groups 1-44 and is the fifth leading cause of mortality in the United states (Heron,2010). The major cause of preventable deaths from these traumas was caused by uncontrollable hemorrhaging (Alam, 2009). If doctors had more time to evaluate and repair the damage, they could prevent deaths caused by uncontrolled hemorrhaging. A new clinical trial using induced hypothermia is being conducted by Samuel A. Tisherman at the University of Pittsburg Medical Center (UMPC) Presbyterian Hospital to enable surgeons to fix the structural damage that would otherwise be fatal. This revolutionary procedure is called
The aim of the final phase of this therapy is to gradually rewarm the patient to the normal body temperature of 37 °C. Gradual rewarming of the patient is strongly recommended as rewarming the patient too quickly can cause a number of adverse side effects such as a sudden arrhythmia that can cause electrolyte shifts, hypoglycemia, and hypotension. Neuromuscular blockers are often administered in conjunction with rewarming to prevent shivering thermogenesis, which can lead to sudden electrolyte disturbances. An ideal rate of rewarming of 0.15 °C to 0.25 °C per hour is recommended in order to minimize the adverse side effects associated with this phase (Peberdy et al., 2010, S770).
Over the last two years, I have had the opportunity of working with astounding physicians providing quality patient care. Through my observations, I have come to understand a doctor has the privilege of sharing someone’s best, worst, and most private moments. I hope to someday have the honor of becoming a physician to care for patients in these moments with the intent of improving the patient’s quality of life as well as preserving their physical and mental well-being. Sometimes patients are seen only as a list of symptoms, a diagnosis, or plan of treatment. However, a patient is so much more; he or she is a human being that should be evaluated and treated as an individual who only wants to get
(Karmiova, 2001) and is predictive of subsequent multiple organ failure, infection and than eventually death in these patients. These conditions have many features common with sepsis. Blood concentrations of various cytokines, soluble receptors and endotoxins increase within as early as 3 hours after cardiac arrest, the magnitude of these changes is associated with the outcome. Activation of blood coagulation without adequate activation of endogenous fibrinolysis is an important pathophysiological mechanism that may contribute to microcirculatory reperfusion disorders (Böttiger, 1995). For patients that undergo CPR and achieve ROSC, their coagulation/anticoagulation and fibrinolysis/antifibrinolsis systems are activated. Anticoagulant factors such as antithrombin, protein S and protein C are decreased and this decrease is associated with transient increases in endogenous activated protein C after resuscitation (Adrie,2005). The stress of total-body oxygen debt also affects adrenal production and function. Although patients have increased plasma cortisol levels they have a relative adrenal insufficiency defined as failure to respond to corticotrophin. This failure to respond causes the adrenal cortex to not be stimulated to secrete the hormones necessary to respond to stress.
Freezing is a complicated process. In ideal conditions, a team of cryonicists wait nearby at the time of death, which greatly increases the chances for the patient to be successfully cryopreserved. However, the suspension procedure can only begin once the patient has been declared legally dead by a physician. Afterwards, steps are taken to postpone the body’s breakdown process. This is done by cooling in ice and water, and maintaining the flow of blood in the body. Cardiopulmonary support (CPS), a method similar to cardiopulmonary resuscitation (CPR) keeps the blood circulating. Drugs are administered to reduce the risk of blood clots. Next, CPS is replaced with a heart-lung machine. The heat-exchanger in the heart-lung machine causes the patient’s