What is Diabetes Mellitus?
Diabetes is a very common disorder. It is the 8th leading cause of death worldwide. It is projected that the number of individuals with diabetes will almost double by 2030.
Diabetes mellitus is a disorder characterized by abnormalities in carbohydrate, protein, and fat metabolism. The most common feature seen in diabetes is increased blood glucose levels. The main reason for this is either a decreased/ absent insulin production or resistance of the body to the action of insulin or both.
The elevated blood glucose levels can lead to long-term complications, especially, in the eyes, kidneys, nerves, heart, and blood vessels.
Diabetes Mellitus can be classified into three main types: Type 1 - Insulin-dependent
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Although it is mostly seen in individuals younger than 30 years, the onset can occur at any age.
Type 2 Diabetes Mellitus
This is the most common type of Diabetes. In Type 2 Diabetes, the body does not respond adequately to insulin. Thus, even in the presence of insulin, the cells cannot effectively take up glucose and hence the blood glucose increases. This puts an extra strain on the beta cells of the pancreas to secrete more insulin to normalize the blood glucose, to the point that they get fatigued and can no longer keep up and hence relative deficiency of insulin develops. This leads to a further increase in the blood glucose.
The impaired insulin function also disturbs the fat metabolism, resulting in increased free fatty acid and triglyceride levels, and at the same time leads to a decrease in the High-density lipoproteins (HDL) which are said to be the ‘good fats’.
Gestational Diabetes (GDM)
It is defined as an increase in blood glucose levels diagnosed during the pregnancy and induced by the pregnancy. The hormones secreted by the placenta lead to the development of an insulin resistant state which is more pronounced during the last three months of the pregnancy. If uncontrolled, it can lead to abnormalities and complications in both the mother and the baby. It can lead to malformation of the heart/kidneys of the baby, low birth weight or even a large baby
Diabetes is a common disease, which can be a serious life-long illness caused by high level of glucose in the blood. This condition is when the body cannot produce insulin or lack of insulin production from the beta cells
"Diabetes mellitus is not a single disease but a group of disorders with glucose intolerance in common" (McCance 674). Diabetes mellitus is a metabolic disorder characterized by hyperglycemia (increased blood sugar) and results from defective insulin production, secretion, and utilization. There are many forms of diabetes. "Diabetes increases the risk of heart and blood vessel disease, amputation, infections, kidney damage, eye problems (including blindness), and nerve malfunction" (Husain). I will
High blood glucose over time damages the blood vessels which makes it easier for blood clots to form increasing the risk of a stroke. Managing diabetes and maintaining blood glucose levels to stay within normal limits helps in preserving the health and wellness of blood vessels in the body. Diet and diabetic medications can help keep blood glucose within normal
Hyperglycemia is a very serious risk for heart disease and strokes. Complications from hyperglycemic diabetes may include coronary heart disease (CHD), heart failure, stroke, arrhythmias, or even death. High blood glucose (sugar) levels over time can lead to excess fatty deposits on the insides of your blood vessel walls. These deposits often affect blood flow, which increases the possibility of blood vessels clogging and/or hardening. As a result, this leads to heart disease. Furthermore, those with diabetic heart disease (DHD) may have less success with heart disease treatments, such as angioplasty or artery bypass grafting. “The common clustering of these risk factors in a single individual has been called the metabolic syndrome.” (Scott 1134) Uncontrolled diabetes, the biggest contributor to heart disease, is almost four times higher for adults than those without diabetes. The best way to prevent diabetic heart disease is to control it by way of reducing the risk factors through diet and lifestyle changes.
The blood glucose level has very limited range for humans to survive and stay healthy. Generally, people are able to remove excess glucose rapidly from the body but this is not the case when they are diagnosed with diabetes and insulin resistant situations. The lack of insulin resistance can also lead to a decrease in glycogen synthesis and storage as it usually converts glucose to energy for cell’s use (Jensen & et al. 2011). When insulin is produced under insulin resistance, the cells are incapable of using them effectively which then leads to high blood sugar level as ketones and ketoacids are produced as an alternative energy source for the body. The rise of ketoacid causes the blood pH acidic and the patient may also be diagnosed with ketoacidosis (Newton & Raskin 2004). There would also be less intake of lipid and more of stored triglycerides as the lipids are effected by the insulin. As the glucose levels increase, the muscle glucose uptake will decrease while the liver glucose production and blood fatty acid concentration will also increase within the body (Lichtenstein & Schwab 2000). Excess glucose within the blood are converted to fat which can lead to Diabetic Dyslipidaemia and furthermore to obesity, hypertension and
He said, diabetes mellitus is a chronic disease that occurs when the body doesn 't make enough of insulin, or the body doesn 't use insulin properly. Insulin is a key to regulation of blood glucose in our body. In types II diabetes a condition of when insulin insensitivity as a result of insulin resistance that decreases insulin production and eventual pancreatic beta-cell failure enough insulin to meet body needs. Impairment of beta- cell also can lead to problems with insulin production and resistance that can interfere with the process of glucose uptake in by cells and muscle. This condition leads to a decrease in glucose transport into the liver, muscle cells, and fat cells which can lead to a condition called hyperglycemia. Hyperglycemia occurs when there is a high level of blood glucose levels in our blood (Concepts Advisory Panel (2015) p.742).
The heart, nerves, blood vessels, kidneys, eyes and other organs can be negatively impacted by uncontrolled diabetes. The goal is to keep the blood sugar normal most of the time to avoid these complications.
Diabetes is a disease in which the body does not produce enough insulin, a hormone needed to convert the sugars and starches that we eat into energy needed for daily life. The cause of the disease is a mystery, but genetics and environment seem to play major roles. There are two kinds of Diabetes, Diabetes Insipidus and the more common Diabetes Mellitus. Diabetes Insipidus is a rare disease caused by a deficiency of vasopressin, a hormone of the posterior pituitary gland that
In type 2 diabetes a person’s body produces insulin, but the pancreas does not produce enough insulin to maintain bodily functions or the body cannot use the insulin the way it is supposed to. When the body is unable to use insulin properly it is known as insulin resistance. “When there isn’t enough insulin or the insulin is not used as it should be, glucose (sugar) can’t get into the body’s cells” (WebMD, n.d.). When this happens glucose builds up in the blood and is not absorbed by the cells, which causes the body to not function properly. Some of the subsequent damage that can develop as a result of this
Diabetes is a chronic disease in which a person’s glucose (blood sugar) is higher than normal. After our bodies have digested foods and turned them into sugar, the pancreas produces insulin. Insulin helps the body take sugar (blood sugar) out of the bloodstream and helps to shuttle it into our cells to be used for energy. If a person has diabetes, their bodies either doesn’t make enough insulin (Type II) or the body doesn’t use the insulin as it should (Type I). Either of these conditions can result in high sugar (glucose) levels (CDC, 2013).
Diabetes mellitus (DM) is a condition in the body that is related to a faulty metabolism. It means that the body’s metabolism is not functioning properly, which leads to adverse effects in the health. The food we ingest, gets broken down into blood sugar (glucose), which is what fuels our body in the form of energy. This converted glucose needs to enter our cells so that it can be used for energy and growth. And in order for the glucose to enter our cells, there needs to be insulin present, which the beta cells of the pancreas is responsible for producing. This hormone is responsible for maintaining glucose level in the blood. It allows the body cells to use glucose as a main
Long-term effects of diabetes can cause many serious complications: heart disease, stroke, blindness, amputations, and kidney disease and nerve damage. These complications are usually progressive and develop over time due to poor control of blood glucose levels. High blood glucose levels cause a narrowing of all the vessels, blockage, and high blood pressure.
Diabetes mellitus (sometimes called "sugar diabetes") is a condition that occurs when the body can 't use glucose (a type of sugar) normally. Glucose is the main source of energy for the body 's cells. The levels of glucose in the blood are controlled by a hormone called insulin, which is made by the pancreas. Insulin helps glucose enter the cells.
Diabetes is a major problem in our society today. Many people have heard about the disease; however, they do not know too much about its complications. Diabetes is a chronic, progressive and lifelong condition that affects the body’s ability to use the energy found in food (WebMD, 2016). Many new cases are confirmed every year and unfortunately, many go undiagnosed for years. Diabetes is a serious disease and need to be taking seriously. The disease can lead to many other health problems such as blindness, nerve damage and kidney diseases. The more the community understand and made aware of the seriousness of the disease, the better it can be control and or prevented.
Hyperglycaemia is when blood sugar levels increase to above the normal. If blood glucose levels remain high for a long time it damages proteins by binding directly to them and building up. This in turn leads to poor peripheral circulation which leads to serious damage to tissues, and