Solve part b please 1. In a study by Cameroni et al. (Nature, Dec. 2021), scientists analyzed the interactionbetween the extracellular domain of the ACE2 protein and the spike proteins frommultiple variants of concern. Below is an example of data collected in this study.SARS-CoV-2Spike protein variantWuhanAlphaBetaDeltaOmicronKD, nM609.62.41.22.4(a) Which of the SARS-CoV-2 variants would be considered the primary binding receptorfor the ACE2 protein? Explain your answer.The Delta SARS-CoV-2 variant would be considered the primarybinding receptor for the ACE2 protein due to its KD value. A lowerKD value means that there is a stronger binding affinity to theACE2 protein. In this case, the variant will the lowest KD value isDelta which indicates it is the primary binding receptor for theACE2 protein.(b) Using the data from the table above, calculate the specificity factor (a) of theinteraction between the ACE2 protein and SARS-CoV-2 variant spike proteins at[ACE2] = 1 nM. Assume that the concentration of each of the SARS-CoV-2 variantspike proteins is the same in the binding reaction. Show your work.

SARS-CoV-2 is an infectious virus that is responsible for the recent COVID pandemic. It is a…

Answered: 1. In a study by Cameroni et al.…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Calculate the specificity factor (a) of the interaction between the ACE2 protein and SARS-CoV-2 variant spike proteins at [ACE2] = 1 nM and 10nM. Show work pls
It is not an easy matter to assign particular func-tions to specific components of the basal lamina, sincethe overall structure is a complicated composite materialwith both mechanical and signaling properties. Nidogen,for example, cross-links two central components of thebasal lamina by binding to the laminin γ-1 chain and totype IV collagen. Given such a key role, it was surprisingthat mice with a homozygous knockout of the gene fornidogen-1 were entirely healthy, with no abnormal phe-notype. Similarly, mice homozygous for a knockout of thegene for nidogen-2 also appeared completely normal. Bycontrast, mice that were homozygous for a defined muta-tion in the gene for laminin γ-1, which eliminated just thebinding site for nidogen, died at birth with severe defectsin lung and kidney formation. The mutant portion of thelaminin γ-1 chain is thought to have no other functionthan to bind nidogen, and does not affect laminin struc-ture or its ability to assemble into the basal lamina.…
describe SARS-CoV2 Spike Protein
A snapshot of a portion of the SARS-CoV-2 spike protein bound to the human ACE2 receptor (taken from PDB) is shown below. The spike protein is in orange and the ACE2 receptor is in green. Within the red-circled region are 2 amino acids connected by a dashed line (added by Dr. David). These amino acids are a tyrosine residue from the spike protein and an aspartate residue from the ACE2 receptor. w cozed
Explain the signifi cance of the observation that peptides such as fMet-Leu-Phe “activate” the phagocytotic (particle-engulfi ng) functions of mammalian leukocytes (white blood cells).
10- 00 O SCNSA-SCN10A CDKN1A HANDI VTI1A SYTI • MYOCD 9 10 11 12 13 14 15 16 17 18 19 20 2122 X Y
Which set of fragment ions is likely from the same population of precursors ions (parent peptide) from Covid-19 spike protein? b ion NFYEPQI+ and y ion +EPQIITTDK b ion VNNTVYDIP+ and y ion +NNTVYD b ion PLSETK+ and y ion +ALDP All of the described choices are likely. None of the described choices are likely.
To construct an “interactome” like the one shown inFigure 9-21, scientists identify all of the protein interactions in a particular tissue or cell type. Comparison ofinteractomes from human muscle versus human braintissue reveals very different patterns. If you were the scientist involved in this study, how would you explainthese results?
33. Band 3 protein exists as a 95-kDa multipass membrane protein that functions as the primary anion exchanger in erythrocytes. Within the red blood cell (RBC) membrane, band 3 binds to spectrin dimers and tetramers indirectly through ankyrin. The spectrin tetramers are bound together by actin and band 4.1 protein, which also binds to band 3 and glycophorin. Null mutations in band 3 occur in the human population. Which one of the following is most likely to decrease in the absence of band 3 protein? a. Osmotic fragility b. Destruction of RBCS in the spleen c. Bile production d. Erythroid production in the bone marrow e. Blood pH
These sequences are derived from the middle region of the covid-19 spike protein. Which choice or choices would not have m/z signature(s) that would allow them to be identified as tryptic peptide(s)? YNENGTITDAVDCALDPLSETK VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEK RVQPTESIV
The codon change (Gly-12 to Val-12) in human rasH that convertsit to oncogenic rasH has been associated with many types ofcancers. For this reason, researchers would like to develop drugs toinhibit oncogenic rasH. Based on your understanding of the Rasprotein, what types of drugs might you develop? In other words,what would be the structure of the drugs, and how would theyinhibit Ras protein? How would you test the efficacy of the drugs?What might be some side effects?
What are the advantages of expressing proteins under study in host organism? And give the 3 major differences between TEM and SEM

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