13.14. On the following figures, genes A and B are on the X chromosome (blue) and both are subject to X inactivation, while genes C and D are on chromosome 17 (an autosome; red). F and S refer to alleles encoding fast- and slow-migrating forms of the corresponding proteins that can be discriminated by electrophoresis. For women 2 and 3 in the figures that follow, indicate all the possible forms of the four proteins that could be expressed in clones made from different individual somatic cells that already had one or more Barr bodies. As an example, some clones from normal woman 1 could express the AF, BF, CF, CS, DF, and DS proteins, while other clones could express the AS, BS, CF, CS, DF, and DS proteins. None of the clones from woman 1 should make both the slow and fast forms of proteins A or B. Woman 2 is a heterozygote for a deletion of the XIC. Woman 3 is a heterozygote for a reciprocal translocation in which parts of the X chromosome and chromosome 17 have exchanged places. Woman 1 XIC BF DF AS DS XIC Woman 2 XIC AF BF DF AS BS DS Woman 3 XIC AF / DS BF AS BS CF DF

Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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13.14. On the following figures, genes A and B are on the X chromosome (bluel and
both are subject to X inactivation, while genes C and D are on chromosome 17 (an
autosome; red). F and S refer to alleles encoding fast- and slow-migrating forms of
the corresponding proteins that can be discriminated by electrophoresis. For
women 2 and 3 in the figures that follow, indicate all the possible forms of the four
proteins that could be expressed in clones made from different individual somatic
cells that already had one or more Barr bodies. As an example, some clones from
normal woman 1 could express the AF, BF, CF, CS, DF, and DS proteins, while other
clones could express the AS, BS, CF, CS, DF, and DS proteins. None of the clones from
woman 1 should make both the slow and fast forms of proteins A or B. Woman 2 is a
heterozygote for a deletion of the XIC. Woman 3 is a heterozygote for a reciprocal
translocation in which parts of the X chromosome and chromosome 17 have
exchanged places.
Woman 1
XIC
AF
BF
CF
DF
AS
BS
CS
DS
XIC
Woman 2
XIC
AF
BF
CF
DF
AS
BS
DS
Woman 3
XIC
AF /
DS
CS
BF
AS
BS
CF
DF
Transcribed Image Text:13.14. On the following figures, genes A and B are on the X chromosome (bluel and both are subject to X inactivation, while genes C and D are on chromosome 17 (an autosome; red). F and S refer to alleles encoding fast- and slow-migrating forms of the corresponding proteins that can be discriminated by electrophoresis. For women 2 and 3 in the figures that follow, indicate all the possible forms of the four proteins that could be expressed in clones made from different individual somatic cells that already had one or more Barr bodies. As an example, some clones from normal woman 1 could express the AF, BF, CF, CS, DF, and DS proteins, while other clones could express the AS, BS, CF, CS, DF, and DS proteins. None of the clones from woman 1 should make both the slow and fast forms of proteins A or B. Woman 2 is a heterozygote for a deletion of the XIC. Woman 3 is a heterozygote for a reciprocal translocation in which parts of the X chromosome and chromosome 17 have exchanged places. Woman 1 XIC AF BF CF DF AS BS CS DS XIC Woman 2 XIC AF BF CF DF AS BS DS Woman 3 XIC AF / DS CS BF AS BS CF DF
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