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- Blood pH is maintained at a range of 7.4. The following set of equations representsthe reactions of the blood buffering system. The pk, for the dissociation ofH,COg into HOg and H* is 6.3.Carbonic AnhydraseCO2 + H2OH2CO3> HCO3- + H+(a) (Calculate the ratio [HCO3 ]/[H,COg] at physiological pH. Show work.(b)) An individual with diabetes presented at an urgent care with fatigue andnausea. Lab tests showed that their blood [HOg ]/[H,COg] ratio was 3.4. Whatwas the pH of the patient's blood? Show work.(c) ) Clinic staff also noticed that the patient was breathing rapidly. What isthe reason for this rapid breathing and how might it help alleviate the patient'scondition?Pharmaceuticals When a medicine is administered orally, the concentration of the drug in the patient's circulation after t minutes is given by C(t) = 0.06t – 0.00021, where Osls 240 and the concentration is measured in mg/L. When does the highest serum concentration occur, and what is that maximum serum concentration?252F%252Fbbniagaraccc.sin.suny.edu%252Fwebapps signment Saved He One of the uses of diazepam is as an antiepileptic that can be administered by slow IV infusion at a rate of 0.5 mg/min for 1 hour. If the infusion solution consists of 6 ml and there are 15 drops per milliliter of solution, how many drops per minute should be administered? drops per minute
- Calculations Involving Units, mcg/mg and Other Measurement of Potency. Show your complete solution. 1. A hospital pharmacy has available 2-mL prefilled syringes containing 80 mg of tobramycinand 1.5-mL prefilled syringes containing 60 mg of tobramycin. The syringes are calibratedin 0.25-mL units. Explain how you would prepare a medication order calling for 110 mgof tobramycin to be added to 100 mL of D5W for intravenous infusion.Calculate the unknown concentration of the PROTEIN C with an absorbance value of A412 given the standard curve indicated in the table below. Write your final answer (NUMBER ONLY) in two decimal places rounded off. Protein concentration (µg/mL) 0 0.02 0.04 0.06 0.08 0.10 Your answer APIENT Absorbance 0.000 0.161 0.284 0.438 0.572 0.762Tirofiban (C22H36N₂O5S MWt = 440.6) is present as tirofiban HCI monohydrate MWt=495.1) at 0.281 mg/mL in a concentrated solution. (C22H36N2O5S.HCI.H₂O A solution for infusion is prepared by extracting 50 mL from a 250 mL bag of 5% glucose s and adding 50 mL of concentrated solution. Sonya who weighs weighs 60 kg requires a tirofiban dose of 0.4 mcg/kg/min for 30 minute- What volume would remain after 30 minutes? Answer: 94.53 mL X The correct answer is: 236 mL
- Calculate the following concentration given thisThe concentration ofacetylcholine (a neurotransmitter) in a sample can be determined from the pH changes thataccompany its hydrolysis. When the sample is incubated with the enzymeacetylcholinesterase, acetylcholine is converted to choline and acetic acid, whichdissociates to yield acetate and a hydrogen ion: In a typical analysis, 15 mL of an aqueous solution containing an unknown amount ofacetylcholine had a pH of 7.65. When incubated with acetylcholinesterase, the pH of thesolution decreased to 6.87. Assuming there was no buffer in the assay mixture, determinethe number of moles of acetylcholine in the 15 mL sample.