Arrange the following sequences in muscle contraction in the correct order. Write your answer using the following pattern "2-6-9-..." excluding the " " marks. 1 [Myosin head binds to myosin-binding sites] 2 [Sarcomere relaxes] 3 [ATP is hydrolyzed] 4 [Sarcomere shortens] 5 [ATP binds to myosin head] 6 [Myosin head swivels towards the M-line] 7 [Another ATP binds to myosin head forming low-energy rigor complex]
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- In the diagram below, label the fine structure of a muscle, down to one of its myofibrils. Identify the basic unit of contraction in a myofibril.Number the following statements in the proper sequence to describe the contraction mechanism in a skeletal muscle cell ( select number from 1 to 12) Action potential (AP) arrive at axon terminal at neuromuscular junction (NMJ) [ Choose ] The muscle cell relaxes and lengthens [ Choose ] SR releases calcium and it binds to troponin [ Choose ] Myosin heads bind to actin and contraction begins [ Choose ] Ion permeability of sarcolemma changes and sodium begins entering muscle cell causing depolarization Calcium flows into presynaptic terminal to initiate neurotransmitter release [ Choose ] AP travels across the entire sarcolemma [ Choose ] Ach is released and binds to receptors on the sarcolemma [ Choose ] Local depolarization (end plate potential) ignites AP in sarcolemma [ Choose ] Troponin moves tropomyosin out of the way of myosin binding sites on actin [ Choose ] AP travels along T tubules [ Choose ] Cross bridge cycling continues until ATP runs out and/or calcium is…Order the following steps of muscle contraction: Drag and drop options into correct order and submit. For keyboard navigation... SHOW MORE ✓ ||| ||| ||| = ||| ||| ||| ||| ||| calcium binds to troponin inducing conformational change in the troponin/tropomyosin complex myosin head unbinds from actin inorganic phosphate group unbinds from myosin myosin binding sites on actin are exposed and myosin head binds to actin ADP unbinds from myosin and new molecule of ATP binds action potential raises the voltage of the myoblast power stroke occurs sarcoplasmic reticulum releases calcium causing large influx of calcium into sarcoplasm X X X X X X X Open
- For the following five events, which is the correct sequence that describes the excitation and contraction of a skeletal muscle fiber? 1. Tropomyosin shifts, exposing the myosin-binding sites on actin. 2. Calcium is released from the sarcoplasmic reticulum and binds to the troponin complex. 3. An action potential is propagated down the transverse tubules. 4. Cycles of myosin cross-bridge formation and breakdown cause the thin filaments to slide toward the center of the sarcomere. 5. An action potential in a motor neuron causes the axon to release acetylcholine, which triggers an action potential in a muscle fiber. 1 → 2 → 3 → 4 → 5 3 → 2 → 4 → 1 → 5 2 → 1 → 3 → 5 → 4 5 → 3 → 2 → 1 → 4 4 → 3 → 1 → 2 → 5Which of the following is the correct sequence of events in the initiation of contraction of a skeletal muscle fiber? Conformational Change in Troponin-Tropomyosin Complex Depolarization of Sarcolemma 1 2 3 4 5 25523 Release of Ca²+ from Sarcoplasmic Reticulum 3 4 2 4 Propagation into Transverse Tubules 4 3 4 3 Acetylcholine Binding to Receptors 5 2Image A Image B Z M F. The images above represent the contracting unit of a muscle fiber. Using the images shown, answer the following questions. Be sure that you label your answers a, b and c. a. What is a contracting unit of a myofibril called? b. Which image represents a myofibril that is fully contracted? c. Explain how you derived your answer to part b. Be sure to use the words for the myofilaments that are involved in muscle contraction in your answer.
- Describe what is happening overall in the first sentence. Then describe, in detail, what is happening in each step below. Include details about what is happening at steps 5 - 7 in terms of calcium and the contraction mechanism (from a different figure). (a) -Axon terminal of somatic motor neuron Muscle fiber ACh- potential Action Na+ Action potential- -Motor end plate- lell Ca2+ released Myosin thick filament 6 + + + ++Arrange the following in statements in the order that they occur during muscle contraction: 1-10 ACh leaves the synaptic knob and enters the synaptic cleft The action potential is carried deep into the muscle cell by T tubules The muscle cell relaxes and lengthens Myosin binds to and pulls on actin, resulting in muscle shortening Calcium attaches to troponin As calcium re-enters the sarcoplasmic reticulum, its concentration at the myofilaments decreases Calcium is released from the sarcoplasmic reticulum Tropomyosin rolls out of the way, exposing actin ACh diffuses across the synaptic cleft and attaches to protein receptors on the sarcolemma, resulting in muscle "excitation" Na+ enters the muscle cell and K+ exits, resulting in an action potential3.4. About human skeletal muscle contraction, what are the correct statements? PHYSIOLOGY_basic (OJO) A muscle fiber is made by the parallel apposition of sarcomers. Generation of force relies on the formation of cross-bridges between actin and myosin filaments. In the process of contraction, adenosine triphosphate (ATP) is required both to drive the actin-myosin association-dissociation cycle and to recycle calcium back to the endoplasmic reticulum. Each muscle fiber is innervated by one neuron only. T tubules are plasma membrane invaginations of the sarcolemma that allow excitation-contraction coupling.
- In normal skeletal muscle contraction, which of the following represents the correct sequence of events? 1. Action potential 2. Ca2+ release into cytoplasm 3. Interaction between actin and myosin filaments 4. Ca2+ is pumped back to cisterns 5. Depolarization of T tubules Answers A-F A 1-2-5-3-4 B C 1-4-5-3-2 1-5-2-3-4 D 5-1-2-3-4 E F 5-4-3-1-2 5-4-1-3-2 OSelect the correct statements regarding myosin-mediated contraction in the sarcomere. Ca2+ is required for the binding of myosin to f-actin. Myosin and f-actin are randomly distributed in the sarcomere. Physical pulling of the actin microfilament requires three distinct conformation changes on myosin that involve ATP binding, ATP hydrolysis and sequential release of inorganic phosphate and ADP. Myosin-mediated contracted is ubiquitous across all el types.Skeletal muscle is described as striated. What are the lighter, thinner stripes noted under the microscope? Group of answer choices troponin actin myosin dystrophin Rather than innervating individual muscle fibers, motor neurons often innervate two or more muscle fibers. The motor neuron and the muscle fibers it innervates are together called a: Group of answer choices motor unit myofibril muscle fascicle motor fascia Fast glycolytic muscle fibers allow for relatively quick ATP energy production by splitting glucose (but eventually leads to fatigue), a process described as: Group of answer choices fermentation aerobic pathway anaerobic pathway ATP reserve use