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Choose the correct answer from the options in brackets. The [positive/negative] standard free‑energy change favors the oxidation of succinate by covalently‑bound FAD. This is consistent with K′eq [ >1 / =1 / <1 ]. Oxidation by NAD+ would require a large, [positive/negative] standard free‑energy change, with K′eq favoring the synthesis of succinate.

Choose the correct answer from the options in brackets. The [positive/negative] standard free‑energy change favors the oxidation of succinate by covalently‑bound FAD. This is consistent with K′eq [ >1 / =1 / <1 ]. Oxidation by NAD+ would require a large, [positive/negative] standard free‑energy change, with K′eq favoring the synthesis of succinate.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Choose the correct answer from the options in brackets.

The [positive/negative] standard free‑energy change favors the oxidation of succinate by covalently‑bound FAD. This is consistent with K′eq [ >1 / =1 / <1 ]. Oxidation by NAD+ would require a large, [positive/negative] standard free‑energy change, with K′eq favoring the synthesis of succinate.

All the dehydrogenases of glycolysis and the citric acid cycle use NAD+ (Eº for NAD+/NADH is -0.32 V) as electron acceptor except succinate dehydrogenase, which uses covalently-bound FAD (E for FAD/FADH2 in this enzyme is 0.050 V). The Eo value for fumarate/succinate is 0.031 V. Calculate the AG' value for the oxidation of succinate using NAD+. AGO Calculate the AG' value for the oxidation of succinate using covalently-bound FAD. AGO 67.55 = -3.667 kJ/mol kJ/mol
Transcribed Image Text:All the dehydrogenases of glycolysis and the citric acid cycle use NAD+ (Eº for NAD+/NADH is -0.32 V) as electron acceptor except succinate dehydrogenase, which uses covalently-bound FAD (E for FAD/FADH2 in this enzyme is 0.050 V). The Eo value for fumarate/succinate is 0.031 V. Calculate the AG' value for the oxidation of succinate using NAD+. AGO Calculate the AG' value for the oxidation of succinate using covalently-bound FAD. AGO 67.55 = -3.667 kJ/mol kJ/mol
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