Cleavage Ligand Precursor Receptor Inactive Receptor Active www 99 Cell Membrane 6. The figure above shows a model of a ligand precursor being cleaved to produce an active ligand that binds to a specific receptor. Which of the following is most likely to reduce the binding of the active ligand to its receptor? (A) A change in the cytoskeletal attachment of transmembrane proteins (B) The presence of a large amount of the precursor form of the ligand (C) An increase in the ratio of the number of unsaturated to the number of saturated fatty acid tails of the membrane lipids (D) A mutation in the receptor gene that causes a substitution of a charged amino acid for a nonpolar amino acid in the ligand binding site of the receptor

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter31: Completing The Protein Life Cycle: Folding, Processing, And Degradation
Section: Chapter Questions
Problem 9P
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Cleavage
Ligand
Precursor
Receptor
Inactive
Receptor
Active
Cell Membrane
6. The figure above shows a model of a ligand precursor being cleaved to produce an active
ligand that binds to a specific receptor. Which of the following is most likely to reduce the
binding of the active ligand to its receptor?
(A) A change in the cytoskeletal attachment of transmembrane proteins
(B) The presence of a large amount of the precursor form of the ligand
(C) An increase in the ratio of the number of unsaturated to the number of saturated
fatty acid tails of the membrane lipids
(D) A mutation in the receptor gene that causes a substitution of a charged amino acid for a
nonpolar amino acid in the ligand binding site of the receptor
Transcribed Image Text:Cleavage Ligand Precursor Receptor Inactive Receptor Active Cell Membrane 6. The figure above shows a model of a ligand precursor being cleaved to produce an active ligand that binds to a specific receptor. Which of the following is most likely to reduce the binding of the active ligand to its receptor? (A) A change in the cytoskeletal attachment of transmembrane proteins (B) The presence of a large amount of the precursor form of the ligand (C) An increase in the ratio of the number of unsaturated to the number of saturated fatty acid tails of the membrane lipids (D) A mutation in the receptor gene that causes a substitution of a charged amino acid for a nonpolar amino acid in the ligand binding site of the receptor
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