Draw a structure for a peptide that gives Gly, Ile & Phe on hydrolysis and fails to react with phenyl isothiocyanate. Mass spectrometry gives a molar mass of 317 for this peptide.
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- Draw a structure for a peptide that gives Ala, Leu & Val on hydrolysis and fails to react with phenyl isothiocyanate. Mass spectrometry gives a molar mass of 283 for this peptide. Draw the predominant structure at pH 7 using the charge tools to adjust formal charges.Draw a structure for a peptide that gives Ala, Leu & Val on hydrolysis and fails to react with phenyl isothiocyanate. Mass spectrometry gives a molar mass of 283 for this peptide. Draw the predominant structure at pH 7 using the charge tools to adjust formal charges. • You do not have to consider stereochemistry. You do not have to explicitly draw H atoms. • Do not include lone pairs in your answei. opy aste ChemDoodle21-43 Give appropriate names for the following compounds: (а) (b) (с) CH;CH,CH,CH2 -C-ci Ph CH, CH,CH-C-N-Ph (d) (e) () H. CH3CH N-ċ-Ph CH3CH,-Č-0-Ph CH3CH 0-C-Ph (g) hoonon (h) (1) CH;CH,O OCH CH, (G) (k) (1) H,C CH- C-N(CH,CH3)2 H;C O.
- 6, The structure originelly proposed For Cordycepic acid, [a] +40.3°, has been + 40.3°, has been shown to be in Correct, suggest to be reason skeptical obout the original Structure, which is given below CO2H 1.29 HO HO.What is the structure that best represents the following amino acid at pH = 10? wolzle H₂N NH₂ O A A HN H₂N B NH₂ i NH₂ OH H₂N C NH3 H₂N NH₂ D OHDraw a structure for a peptide that gives Ala, Leu & Val on hydrolysis and fails to react with phenyl isothiocyanate. Mass spectrometry gives a molar mass of 283 for this peptide. Draw the predominant structure at pH 7 using the charge tools to adjust formal charges. You do not have to consider stereochemistry. You do not have to explicitly draw H atoms. • Do not include lone pairs in your answer. They will not be considered in the grading. 85 کر ChemDoodleⓇ ル نے
- Treatment of a new protein with dansyl chloride reveals two (2) dansyl-labelled derivatives of amino acids, alanine and methionine. What can you deduce about the structure of the proteinfrom these results?Structure pK, K. Name NH; CHCH,-O 2.20 (СО,Н) 9.31 (NH,) 6.3 X 10-3 4.9 x 10-10 Phenylalanine CO,H 7.11 x 10-3 6.34 x 10-8 2.148 * 7.198 Phosphoric acid* (hydrogen phosphate) НО — Р— Он 12.375 4.22 X 10-13 OH (1.5) 6.78 3 x 10-2 1.66 x 10-7 HP- он Phosphorous acid (hydrogen phosphite) OH 1.12 x 10-3 3.90 x 10-6 2.950 Phthalic acid (benzene-1,2-dicarboxylic acid) 5.408 cO,H Piperazine (perhydro- 1,4-diazine) 5.333 9.731 4.65 x 10-6 1.86 X 10-10 11.125 7.50 x 10-12 Piperidine 1.12 x 10-2 2.29 x 10-11 -co,H 1.952 (СO,Н) 10.640 (NH,) Prolinc +H 4.874 1.34 x 10-5 Propanoic acid CH,CH,CO,H H,C=CHCO,H 4.258 5.52 x 10-5 Propenoic acid (аcrylic acid) 10.566 2.72 x 10-11 Propylamine CH;CH,CH,NII; 5.20 6.3,X 10-6 Pyridine (azine) Pyridine-2-carboxylic acid (picolinic acid) (1.01) (CO,H) 5.39 (NH) 9.8 x 10-2 4.1 x 10-6 co,H HO,C Pyridine-3-carboxylic acid (nicotinic acid) 2.03 (CO,H) 4.82 (NH) 9.3 x 10-3 1.51 x 10-s NH+ 1.4 (POH) (u = 0.1) 3.44 (OH) (1p. = 0.1) 6.01 (POH) (u = 0.1) 8.45 (NH) (u =…Select the correct representation of this aminoacid in aqueous solution at the stated pH values. pKa (a-CO₂H) = 2.20 pK₂ (α-NH₂) = 9.11 pKa (side chain OH) = 10.07 pl = 5.63 HO Lont out on on OH OH NH₂ NH₂ NH₁ HO NH₂ B D at pH 1 HO NH₂ of of an OH NH₂ NH₂ NH3 O E F G at pH 9.59 at pH 13. at pH 5.63 (the isoelectric point) HO OH HO [Choose ] [Choose ] [Choose ] [Choose ] an NH3 H OH
- (b) Using alanine as an example, draw possible conformations of alanine in a peptide chain and identify which conformer is favoured. (c) Discuss how considering 'allylic strain' [see pages 33-39 of handout 1] can explain the favoured conformation in part b above, and how this is relevant to the B-sheet conformation in peptides/proteins.(b) Describe how the charge of some amino groups in a protein might differ at pH 9.0 and pH 5.0. the charge on the amino group will differ at pH 5 and pH 9 which will depend on the pKa of the amino acid. (c) Describe how the charge of some carboxyl groups in a protein might differ at pH 9.0 and pH 5.0. charge on carboxyl group will differ at pH 5 and pH 9 which will depend on the pKa of the amino acid. (d) Given your answers to parts (b) and (c), what kind of intramolecular interactions in beta-galactosidase are most likely to be affected by a change in pH from 9.0 to 5.0? (e) Could the interactions you mention in part (d) affect the catalytic activity of beta-galactosidase?n5of 15 > Glycine is a diprotic acid, which can potentially undergo two dissociation reactions, one for the a-amino group (–NH;), and the other for the carboxyl (–COOH) group. Therefore, it has two pK, values. The carboxyl group has a pKj of 2.34 and the a-aminc group has a pK2 of 9.60. Glycine can exist in fully deprotonated (NH, –CH, –COO"), fully protonated (NH† –CH, -COOH), or zwitterionic form (NH;-CH,-CO0-). Match the pH values with the corresponding form of glycine that would be present in the highest concentration in a solution of that pH. fully deprotonated form fully protonated form zwitterionic form NH,–CH,-COO" NH; –CH,-COOH NH -CH, -COO- Answer Bank pH 7.0 pH 1.0 pH 8.0 pH 11.9 PН 6.0 MacBook Air DII DD F4 F5 F6 F7 F8 F9 F10 F11 F12 $ & * 4 5 6. 7 8. R T. Y U %D F H J K + || * 00 %24