Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter21: Lipids
Section: Chapter Questions
Problem 21.91P
Related questions
Question
Show how lidocaine, one of the most widely used injectable anesthetics, can be prepared from benzene and compounds containing no more than four
carbons.
Expert Solution
Step 1
Lidocaine preparation can be done from benzene in the following steps-
Step 1: Nitration reaction of Benzene in presence of HNO3 and H2SO4.
Step 2: Reduction of nitro-product by using Palladium as a catalyst.
Step 2
Step 3: Further reacting product with acyl chloride as shown below.
Step 4: Sulphonation of the product in step 3 and followed by Friedel craft alkylation reaction in excess of CH3Cl as shown below.
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