NH2 NH2 H NH2 NH2 H. C=Ñ C=N C=N C=N-H pka = 2.17 -H* pk = 8.99 -H* pk = 12.5 -H* H. H. NH NH NH NH +H" +H* +H* H (CH2)3 H (CH,)3 (CH2)3 (CH2)3 H-N+ С —СООН H-N C-CO H,N-C-COO H,N-C H H H H H II II IV

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 4.4P
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The amino acid arginine ionizes according to the following scheme: (a) Calculate the isoelectric point of arginine. You can neglect contributions
from form I. Why?
(b) Calculate the average charge on arginine when pH = 9.20. 
(c) Is the value of average charge you calculated in part b reasonable, given
the pI you calculated in part a? Explain your answer

NH2
NH2
H
NH2
NH2
H.
C=Ñ
C=N
C=N
C=N-H
pka = 2.17
-H*
pk = 8.99
-H*
pk = 12.5
-H*
H.
H.
NH
NH
NH
NH
+H"
+H*
+H*
H
(CH2)3
H
(CH,)3
(CH2)3
(CH2)3
H-N+
С —СООН
H-N
C-CO
H,N-C-COO
H,N-C
H
H
H
H
H
II
II
IV
Transcribed Image Text:NH2 NH2 H NH2 NH2 H. C=Ñ C=N C=N C=N-H pka = 2.17 -H* pk = 8.99 -H* pk = 12.5 -H* H. H. NH NH NH NH +H" +H* +H* H (CH2)3 H (CH,)3 (CH2)3 (CH2)3 H-N+ С —СООН H-N C-CO H,N-C-COO H,N-C H H H H H II II IV
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