Suppose that the circulating concentration of hor-mone is 10–10 M and the Kd for binding to its receptor is 10–8M. What fraction of the receptors will have hormone bound?If a meaningful physiological response occurs when 50% ofthe receptors have bound a hormone molecule, how muchwill the concentration of hormone have to rise to elicit aresponse? The fraction of receptors (R) bound to hormone(H) to form a receptor–hormone complex (R–H) is [R–H]/([R] + [R–H]) = [R–H]/[R]TOT = [H]/([H] + Kd).
Suppose that the circulating concentration of hor-mone is 10–10 M and the Kd for binding to its receptor is 10–8M. What fraction of the receptors will have hormone bound?If a meaningful physiological response occurs when 50% ofthe receptors have bound a hormone molecule, how muchwill the concentration of hormone have to rise to elicit aresponse? The fraction of receptors (R) bound to hormone(H) to form a receptor–hormone complex (R–H) is [R–H]/([R] + [R–H]) = [R–H]/[R]TOT = [H]/([H] + Kd).
Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter17: The Endocrine System
Section: Chapter Questions
Problem 1ILQ: Visit this link (http://openstaxcollege.org/l/hormonebind) to watch an animation of the events that...
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Question
Suppose that the circulating concentration of hor-
mone is 10–10 M and the Kd for binding to its receptor is 10–8
M. What fraction of the receptors will have hormone bound?
If a meaningful physiological response occurs when 50% of
the receptors have bound a hormone molecule, how much
will the concentration of hormone have to rise to elicit a
response? The fraction of receptors (R) bound to hormone
(H) to form a receptor–hormone complex (R–H) is [R–H]/
([R] + [R–H]) = [R–H]/[R]TOT = [H]/([H] + Kd).
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