The following image shows Nondisjunction. Which of the following cells will suffer from a genetic disorder due to the occurence of Nondisjunction:
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- A female patient 19 years old, whose symptoms areanemia and internal bleeding due to a massive buildupof leukemic white blood cells, is diagnosed withchronic myelogenous leukemia (CML). Karyotypeanalysis shows that the leukemic cells of this patientare heterozygous for a reciprocal translocation involving chromosomes 9 and 22. However, none of thenormal, nonleukemic cells of this patient contain thetranslocation. Which of the following statements istrue and which is false?a. The translocation results in the inactivation (loss offunction) of a tumor-suppressor gene.b. The translocation results in the inactivation (loss offunction) of an oncogene.c. There is a 50% chance that any child of this patientwill have CML.d. This patient is a somatic mosaic in terms of thekaryotype.e. DNA extracted from leukemic cells of this patient,if taken up by normal mouse tissue culture cells,could potentially transform the mouse cells intocells capable of causing tumors.f. The normal function of the…A normal female is discovered with 45 chromosomes, one ofwhich exhibits a Robertsonian translocation containing most ofchromosomes 18 and 21. Discuss the possible outcomes in heroffspring when her husband contains a normal karyotype.6) The plant Haplepoppus gracilis is diploid (2n = 4). Inside each cell (represented here by the oval) there are four total chromosomes: one long pair (represented by "A" and "a") and one short pair (represented by "B" and “b"). The following diagrams represent possible anaphases of this cell during meiosis or mitosis. The lines represent chromosomes/chromatids being pulled to either the north or south pole of the cell, and the vertex of each "V" represent the centromere which would be attached to kinetochore microtubules. For representative cells 1– 12, say if the diagram represents a cell in anaphase I of meiosis I, anaphase II of meiosis II, anaphase of mitosis, or shows an impossible situation. If the situation is impossible, explain why. い。 VA Vb VA VB VV. V b Va VB VAVA Vo VB ^^ ^ が VaVA Vo VB くs
- illustrate and briefly describe the alignment, pairing, and disjunction ofsister chromatids during mitosis. Include the molecular complexes cohesin and shugoshin and the enzyme separase.A colleague e-mails you saying that she has identified an interesting chromosome variation at 21q13. In discussing this discovery with a friend who is not a cytogeneticist, explain how you would describe this location, defining each term in the chromosome address 21q13.Name the disorder with choromosome compliment 22 pairs of autosomes +XXY?
- Considering the following chromosome which is represented as a series of genes on each arm separated by the centromere. Describe the type of mutation required to produce each of the mutant chromosomes below. ABCDEFG*HIJKLMNOverall, meiosis and mitosis are analogous processes involving many of the same proteins. However, some proteins function uniquely in each of these cell-division events. Explain the meiosis-specific function of the following: (a) Ime2, (b) Rec8, (c) monopolin.Using individual data for Allium cepa, express the number of cells in each of the different stages of mitosis as a percentage of the total number of cells in mitosis, and obtain the average across the three fields of view Enter the value for prophase as a whole number (no decimals or units). Total number of cells in Number of cells in: A.cepa root tip field of view P M T Field 1 181 16 4 Field 2 7 5 147 12 8. Field 3 112 11
- Rice has a chromosome number of 2n = 24. If different aneuploids are available in rice, identifythe specific aneuploidy that shows the following chromosomal configurations at diakinesis ormetaphase I. Also provide the formula and chromosome number of the different aneuploids. Complete the table. Chromosome configuration at diakinesis or metaphase I Specific Type of Aneuploidy Formula (e.g. 2n+1) Chromosome number (2n=24) Types of gametes n, n+1, n+2, n-1, n-2) a. 1 III + 11 II b. 1 IV + 11 II c. 1 I + 11 II d. 11 II e. 2 I + 10 IIName the disorder with the following chromosome complement.(i) 22 pairs of autosomes + X X Y(ii) 22 pairs of autosomes + 21st chromosome + XYAssume that the diploid number of a certain species is four chromosomes, two large and two small (2n=4). a) Of the following figures, which represents a 3n (triploid) cell in mitotic metaphase? b) For each of the wrong answers from part (a) above, explain briefly why it cannot represent a triploid cell in mitotic metaphase.
