Transcriptional activator proteins are modular (a) The complete Gal4 dimer Activation domain Gal4 DNA-binding domain lacz ON Gal4 site (b) Gal4 lacking the activation domain lacz OFF Gal4 site (e) LexA lacking the activation domain DNA-binding, domain lacz OFF LexA site (d) Gal4-LexA hybrid Gal4 activation domain- LexA DNA-binding domain lacz ON LexA site AL structural FIGURE 12-7 Transcriptional activator proteins have multiple, separable domains. (a) The Gal4 protein has two domains and forms a dimer. (b) The experimental removal of the activation domain shows that DNA binding is not suficient for gene activation. (c) Similarly, the bacterial LexA protein cannot activate transcription on its own, but, when fused to the Gal4 activation domain (d), it can activate transcription through LexA-binding sites. AL structural se and ATP, it n turn causes iption factors 3, Gal80, and or absence of onal regulator on and bacte-
Transcriptional activator proteins are modular (a) The complete Gal4 dimer Activation domain Gal4 DNA-binding domain lacz ON Gal4 site (b) Gal4 lacking the activation domain lacz OFF Gal4 site (e) LexA lacking the activation domain DNA-binding, domain lacz OFF LexA site (d) Gal4-LexA hybrid Gal4 activation domain- LexA DNA-binding domain lacz ON LexA site AL structural FIGURE 12-7 Transcriptional activator proteins have multiple, separable domains. (a) The Gal4 protein has two domains and forms a dimer. (b) The experimental removal of the activation domain shows that DNA binding is not suficient for gene activation. (c) Similarly, the bacterial LexA protein cannot activate transcription on its own, but, when fused to the Gal4 activation domain (d), it can activate transcription through LexA-binding sites. AL structural se and ATP, it n turn causes iption factors 3, Gal80, and or absence of onal regulator on and bacte-
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
In any experiment, controls are essential in order to determine the specific effect of changing some parameter.
In Figure 12-7, which constructs are the “controls” that
serve to establish the principle that activation domains
are modular and interchangeable?
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