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- Estimate the binding affi nity of a ligand for its receptor from the followingdata:Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of action. Note: Explain it conscisely and preciselyThe Structure of the acetylcholine receptor is shown below: A. Knowing the amino acid sequence of this protein, what tool would you use to identify the membrane-spanning region? Explain how it works.
- A quanta holds about 10,000 molecules of ACh. How many quanta are exocytosed during a single presynaptic AP? What controls or determines the total number of quanta released? Is this under physiological control?A common membrane-bound intermediary between the receptor and the effector protein within the plasma membrane is the __________________.The NMDA receptor is described as a "coincidence detector" allowing it to detect concurrent activities in the pre- and postsynaptic cells. What are the 2 biochemical properties of the NMDA receptor that allow it to detect concurrent activities in the pre- and postsynaptic cells?
- A) Please explain what a G protein coupled receptor is. Please explain how G protein interacts with this receptor. B) Please explain the kind of reactions that follow binding a specific ligand to a G protein coupled receptor. What do these reactions do in the cell? C) How do these reactions work in the cell. What is the function of these reactions in the cell? How do the reactions proceed?Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of action.you have been asked to develop a drug that could inhibit an enzyme linked receptor. what are the potential pharmacological targets you could design your drug to interact with. which one should you choose and why