When considering an intramolecular Aldol addition that could make a 6-membered ring, what is the main deciding factor for Nu and E+? 1. electrophilicity of the carbonyl determines E+ (aldehyde if possible) because CH pKas are similar 2. CH pKas determines the Nu (aldehyde) because electrophilicity is similar 3. mixtures will always happen, there is no selectivity 4. both CH pKa and electrophilicity are equally important

When considering an intramolecular Aldol addition that could make a 6-membered ring, what is the main deciding factor for Nu and E+? 1. electrophilicity of the carbonyl determines E+ (aldehyde if possible) because CH pKas are similar 2. CH pKas determines the Nu (aldehyde) because electrophilicity is similar 3. mixtures will always happen, there is no selectivity 4. both CH pKa and electrophilicity are equally important

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter16: Synthesis Workshop 1

Section: Chapter Questions

Problem 33CTQ

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