Which of the following statements is/are TRUE for the Krebs' cycle? Reaction 1: condensation of acetyl-CoA and oxaloacetate; produces H20. Reaction 3: oxidation of isocitrate to a-ketoglutarate; produces NADH and CO2. Reaction 6: oxidation of succinate to fumarate; produces FADH2 and CO2 Reaction 5: hydrolysis of succinyl-CoA to succinate; produces ATP.

Which of the following statements is/are TRUE for the Krebs' cycle? Reaction 1: condensation of acetyl-CoA and oxaloacetate; produces H20. Reaction 3: oxidation of isocitrate to a-ketoglutarate; produces NADH and CO2. Reaction 6: oxidation of succinate to fumarate; produces FADH2 and CO2 Reaction 5: hydrolysis of succinyl-CoA to succinate; produces ATP.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...

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Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is inhibited byÂ· NIADH. Pyruvate dehydrogenase is inhibited by AÎ¤Î¡. Citrate synthase is inhibited by NADH. Succinyl-CoA activates citrate synthase. Acetyl-CoA activates pyruvate carboxylase.
The krebs cycle has 8 enzymes: citrate synthase, aconitase, isocitrate dehyrogenase, a-ketoglutarate dehydrogenase, succinyl –CoA synthease, succinate dehyrogenase, fumarase and malate dehyrogenase. a)Write name the cofactors required by each enzyme reaction. b)For each enzyme determine which of the following deascribes the type of reactions catalyzed: condensation (Carbon-carbon bond formation), dehydration (Loss of water), hydration (addition of water), decarboxylation (loss of CO2), oxidation-reduction; subsrate level phospohorylation; isomerization.
Identify the Krebs cycle enzyme that consumes a 3-carbon substrate molecule, producing a 2- carbon product molecule (attached to acetyl-CoA), along with NADH, and one molecule of CO2. succinyl CoA synthetase a-ketoglutarate dehydrogenase pyruvate dehydrogenase isocitrate dehydrogenase malate dehydrogenase
Below is an image of the Krebs cycle: acetyl-CoA oxaloacetate COASH H20 NADH NAD* H20 malate citrate fumarate isocitrate FADH2 NAD* CO2 FAD АТР NADH + ADP succinate GTP NAD+ a-ketoglutarate H20 GDP NADH + CO2 COASH succinyl CoA COASH Consider the conversion of succinate to fumarate, which is coupled with the production the electron carrier FADH2. If this reaction was NOT coupled with the production of FADH2 (and only catalyzed the conversion of succinate to fumarate), how would this impact ATP production through cell respiration? OATP production would stop because no high energy electron carriers would be produced ATP production would still occur, but there would be a much lower ATP yield because a large number of electron carriers are no longer being made ATP production would stop because without FADH2 we will no longer have electrons moving through the electron transport chain ATP production would still occur, but there would be a slightly lower ATP yield because a small number of…
Most fatty acids have an even number of carbons and, therefore, are completely metabolized to acetyl-CoA. A fatty acid with an odd number of carbonsis metabolized to acetyl-CoA and one equivalent of propionyl-CoA. The following two reactions convert propionyl-CoA into succinyl-CoA, a citric acidcycle intermediate, so it can be further metabolized. Each of the reactions requires a coenzyme. Identify the coenzyme for each step. From what vitaminsare the coenzymes derived? (Hint: see Chapter 23.) COO− COO−CH2CH2methylmalonyl-CoA succinyl-CoA CH3CH2 SCoA
One of the regulators of the TCA cycle is succinyl CoA. Discuss the rationale for this molecule to be used to regulate the TCA cycle. What is the metabolic role of succinyl CoA?
Several pathways exist in different organisms for the metabolism of propionyl-CoA. Most organisms utilizethe pathway that feeds into the citric acid cycle via succinyl-CoA. Another metabolic route used by Clostridium kluyveriis a "continuation of -oxidation" and consists of the following enzymatic reactions: (a) propionyl-CoA is converted toacryloyl-CoA; (b) formation of 3-hydroxypropionyl-CoA; (c) conversion to malonyl semialdehyde CoA; (d) productionof malonyl-CoA, which is then (e) decarboxylated to produce acetyl-CoA. Outline the above steps between propionylCoA and acetyl-CoA. Show structures for the metabolites and indicate appropriate cofactors (free or bound) that may beinvolved.
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The products of pyrimidine base catabolism, β-alanine and β-aminoisobutyrate, can be further degraded to acetyl-CoA and succinyl-CoA, respectively. Can you suggest the types of reaction required to accomplish these transformations?
Complete the following paragraph describing the fate of the second 14CO-acetyl-CoA molecule incorporated into the glyoxylate cycle. The glyoxylate produced in the isocitrate reaction combines with a (A.) 2nd molecule of oxoaloacetate, B.) 2nd molecule of succinate, C.)2nd molecule of acetyl coa) in the malate synthase reaction. Malate is (A.Chiral, B.diasteromeoic C.)Achiral) ; therefore, the oxaloacetate produced from glyoxylate will be labeled at (A.Either of carboxylate carbon B. specifically at methylene carbon C. Specifically at carbonyl carbon D. Specifically at carboxylate carbon bonded to methylene).
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The citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options, answering with only one option is incorrect. Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4