Concept explainers
Interpretation:
How the energy releasing steps of glycolysis are reversed in gluconeogenesis has to be explained.
Concept Introduction:
Glycolysis: This is the
Gluconeogenesis: This process of synthesis of glucose or glycogen from non-carbohydrate sources is called gluconeogenesis.
Substrate for gluconeogenesis
- Glycogenic amino acid
- Glycerol
- Pyruvate
- Lactate
- Intermediate of TCA cycle.
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Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
- Name the key enzymes of gluconeogenesis. Explain how lactate is converted to glucose.arrow_forwardList all of the regulatory enzymes from both Glycolysis and Gluconeogenesis, and under each, list the (-) inhibitors and the (+) activators.arrow_forwardWhy is it important that gluconeogenesis is not the exact reversal of glycolysis?arrow_forward
- Define Glycolysis and Gluconeogenesis. How GLYCOLYSIS and GLUCONEOGENESIS does reciprocally regulated in the body? Explain it.arrow_forwardc) Cooperation between glycolysis and gluconeogenesis is important to ensure the glucose-subjected energy demands of specific cells are met. Explain this statement.arrow_forwardIdentify the two stages of the pentose phosphate pathway, and explain how the pathway is coordinated with glycolysis and gluconeogenesis.arrow_forward
- Define GLUCONEOGENESIS. Give three reasons why is gluconeogenesis important in the Cori cycle?arrow_forwardIn simple terms explain why gluconeogenesis is important?arrow_forwardHow many steps in gluconeogenesis are not the exact reversal of the steps in glycolysis? What kind of conversion of substrate to product does each involve? What is the common theme in each of these reactions?arrow_forward
- Explain why pyruvate cannot be converted to glucose in an exact reverse of the glycolysis pathway.arrow_forwardHow are the irreversible reactions of glycolysis bypassed in gluconeogenesis?arrow_forwardDescribe the role of fructose-2,6-bisphosphate in regulating gluconeogenesis and glycolysis.arrow_forward
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