CHAPTER 1
The Problem and Its Background
Introduction
Diabetes is a systemic disease caused by a decrease in the secretion of insulin or reduced sensitivity or responsiveness to insulin by target tissue. (Beale, et al., 2011) The incidence of diabetes is growing rapidly in the United States and worldwide. An estimated 347 million people around the world are afflicted with diabetes. (Whalen, et al., 2012) According to World Health Organization (WHO), Diabetes prevalence among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. It is the major cause of blindness, kidney failure, heart attack, stroke and limbic amputation. World Health Organization (WHO) projects that diabetes will be the 7th leading cause of death in 2030. It is a complex and costly disease that can affect nearly every organ in the body and result in devastating consequences. The leading cause of non-traumatic lower extremity amputations, renal failure, and blindness in working-age adults, diabetes is also a major cause of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital malformations, perinatal mortality, and disability. (Cefalu, 2000) Insulin therapy and oral hypoglycemic agents have demonstrated improvement in glycaemic control. However, Insulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage.
Diabetes is a disease where the body is unable to produce or use insulin effectively. Insulin is needed for proper storage and use of carbohydrates. Without it, blood sugar levels can become too high or too low, resulting in a diabetic emergency. It affects about 7.8% of the population. The incidence of diabetes is known to increase with age. It’s the leading cause of end-stage renal disease in the US, and is the primary cause of blindness and foot and leg amputation. It is known to cause neuropathy in up to 70% of diabetic patients. Individuals with diabetes are twice as likely to develop cardiovascular disease. There are two types of diabetes: Type 1 and Type 2.
The American Diabetes Association (2004) defines diabetes as a subset of metabolic diseases associated with hyperglycemia secondary to insulin failing to release, act, or both. Complications related to chronic diabetes can be detrimental to one’s health including but not limited to: heart disease, stroke, kidney disease, amputations, blindness, and other optical diseases. Furthermore, the prevalence of diabetes is rising at an astronomical rate within the United States as well as internationally. According to the Center for Disease Control and Prevention (CDC) (2016) an estimated 29 million people suffer with diabetes and 86 million are prediabetic within the United States (US). Without major interventions from the healthcare community,
Diabetes mellitus (DM) is a pandemic that affects millions of people. The growth rate of unrecognized pre-diabetes in America is expected to rise up to 52% by 2020 (Lorenzo, 2013). As the prevalence of diabetes increases, so will the complications and burden of the disease. One of the leading causes for cardiovascular disease, renal failure, nontraumatic lower limb amputations, stroke, and new cases of blindness is DM (Lorenzo, 2013).
Uncontrolled diabetes can affect nearly every organ of the body; of which, heart disease and kidney failure are most commonly impacted. Known as diabetes mellitus, a collective term for various blood abnormalities, the term diabetes refers to either a scarcity of insulin in the body or the body’s inability to accept insulin. Though the symptoms of diabetes are manageable, many are unaware as to having it. According to the CDC report “2011 Diabetes Fact Sheet,” approximately 6 million people in the United States have undiagnosed diabetes. Undetected, diabetes can become deadly. In a recent World Health Organization report “Diabetes Action Now: An Initiative of the World Health Organization and the International Diabetes Federation,” it
2. “Among adults with diagnosed diabetes (type 1 or type 2), 12% take insulin only, 14% take both insulin and oral medication, 58% take oral
Diabetes is a growing concern and health challenge for the American people (b). Diabetes is a condition in which the body cannot react to insulin appropriately or either cannot produce insulin efficiently (w). “Without a properly functioning insulin signaling system, blood glucose levels become elevated and other metabolic abnormalities occur, leading to the development of serious, disabling complications” (w). There are numerous forms of diabetes amongst the nation, however, there are three main forms of diabetes. Most people have heard of type one diabetes, type two diabetes, and gestational diabetes because they are common. Type two diabetes deals with a resistance to insulin, while
Diabetes is a disease that affects the body’s ability to produce or use insulin. It is a precursor to numerous other diseases, which can quickly deteriorate patient’s health if
Diabetes has become a widespread epidemic, primarily because of the increasing prevalence and incidence of type 2 diabetes. Diabetes is an endocrine disease in which the body has either a shortage of insulin or a decrease ability to use insulin or both. Insulin is a hormone that allows glucose to enter the cells and be converted into energy. Diabetes can be characterized as a prevailing, incapacitating, and deadly disease. There are a number of risk factors that increase a person’s tendency toward developing type II diabetes. Modifiable risk factors include obesity, physical inactivity and poor dietary habits are just a few. The
Diabetes continues to be a growing problem for the United States population especially type 2 diabetes, which “accounts for about 90% to 95% of all diagnosed cases of diabetes”(Center for Disease Control and Prevention (CDC), 2014). Type 2 diabetes, formally known as adult onset diabetes, is defined as a “disorder of insulin resistance in which the cells primarily within the muscle, liver, and fat tissue do not use insulin properly. As the need for insulin rises the cells in the pancreas gradually lose the ability to produce enough hormone”(CDC, 2014). Diabetes as a whole affects about “9.3% of the US population or 29.1 million people” (American Diabetes Association (ADA), 2014; CDC, 2014). Despite the high prevalence of the disease, it is only going to continue to grow if nothing is done to correct the problem. The “United States spent an estimated $245 billion on diabetes in 2012” (ADA, 2014; CDC, 2014). This outrageous number and the drastic impact diabetes has on health should emphasis the need to reduce the diabetic population in the future.
Diabetes is a problem that is expanding across the nation due to various factors that may be avoided such as bad eating habits, lack of exercise and education. These components can all be reversed, which will result to a diabetic free life. According to Diabetes Research Institute, “the most common form of diabetes is called type 2, or non-insulin dependent diabetes”. People with type 2 are able to produce some of their own insulin, yet often, it’s not enough (Diabetes Research Institute, 2016). Diabetes is the 7th leading cause of death in the United States and effects over 23.6 million people (Healthy People, 2014).
According to Born (n.d.), diabetes has become a growing concern throughout the world with an increase of diabetes related cases by 4.1 percent since 1985. There are currently 285 million people suffering from diabetes and it is estimated that this number will increase to 438 million by 2030. Diabetes cases are not only reported among adults but also children with 18.8 million diagnosed cases and 7 million undiagnosed. In the United
Nobel Prize winner Dr. Fredrick Banning once said, “Insulin is not a cure for diabetes; it is a treatment. It enables the diabetic to burn sufficient carbohydrates so that proteins and fats may be added to the diet in sufficient quantities to provide energy for the economic burdens of life”(Banning, 1928). The American Diabetes Association (ADA), states that 9.3% of the population has diabetes, which is why it was the 7th leading cause of death in the Unites States in 2010. The Center for Control Disease (CDC), states individuals younger than 20 years were newly diagnosed with Type 2 Diabetes annually (CDC, 2010). Physicians often instruct patients affected by Type 2 diabetics, to watch their diet and sustain a healthy, more active lifestyle.
When people think of causes of death, the big names that come up are usually cancer, heart disease, stroke, Alzheimer’s, and suicide. These are all huge killers, but the underestimated, unthought-of, underdog of them all might just be diabetes. Diabetes is the 7th leading cause of death, with an estimated 29 million suffering from the disease and a prediction that 1 in 3 born in 2000 will develop it. In 2005, 233, 619 deaths were due to diabetes and the rate of diabetes development between 2005-2007 increased 13.5%. (CDC, National Diabetes Statistic Report, 2014) Diabetes is a serious disease that isn’t going away. It is the leading cause of blindness, end stage renal disease, and non-traumatic amputations. Diabetes can seemingly appear out of thin air, it can be genetic, it can have symptoms, it can go unnoticed for long periods of time, and as with many other life endangering diseases, it has no cure. The types of diabetes along with their medical therapies and natural preventative measures will be discussed in detail.
Diabetes is a major problem in our society today. Many people have heard about the disease; however, they do not know too much about its complications. Diabetes is a chronic, progressive and lifelong condition that affects the body’s ability to use the energy found in food (WebMD, 2016). Many new cases are confirmed every year and unfortunately, many go undiagnosed for years. Diabetes is a serious disease and need to be taking seriously. The disease can lead to many other health problems such as blindness, nerve damage and kidney diseases. The more the community understand and made aware of the seriousness of the disease, the better it can be control and or prevented.
Diabetes Mellitus is “a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. It is a disease which is caused by the insufficient insulin secretion or decrease in the peripheral effects of insulin. It is a serious problem in terms of morbidity and mortality. The hyperglycemia is associated with long term damage, dysfunction and failure of various organs especially the eyes, kidneys, nerves, heart and blood vessels. It’s associated with many complications which includes blindness of the eyes and amputations of the extremities. It is also associated with neuropathy, retinopathy, and cardiovascular diseases which lead to mortalities.