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Explain how human cells compensate for the X-linked
gene dosage difference in XX and XY nuclei.
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- Barr bodies are formed to adjust X chromosome dosage in species other than humans, such as Drosophila (fruit flies) and C. elegans (nematodes). True or False ?Describe the molecular process of X-chromosome inactivation.This description should include the three phases of inactivationand the role of the Xic. Explain what happens to the X chromosomes during embryogenesis, in adult somatic cells, and duringoogenesis.Outline the molecular steps in the process of X-chromosomeinactivation (XCI). Which step plays a key role in choosing whichof the X chromosomes will remain active and which will beinactivated?
- Explain why a person with Klinefelter Syndrome (XXY) still exhibits abnormal phenotypes despite the fact that one of the extra X Chromosome is inactivated practically leaving an XY active sex chromosomes similar to a normal male?Following X-chromosome inactivation, most of the genes on theinactivated X chromosome are silenced. Explain how. Name onegene that is not silenced.In Drosophila, a heterozygous female for the X-linkedrecessive traits a, b, and c was crossed to a male that phenotypically expressed a, b, and c. The offspring occurred inthe following phenotypic ratios.+ b c 460a + + 450a b c 32+ + + 38a + c 11+ b + 9 No other phenotypes were observed.(a) What is the genotypic arrangement of the alleles ofthese genes on the X chromosome of the female?
- In humans, dosage compensation is accomplished by: inactivating one X chromosome in female somatic cells inactivating one homolog from each homologous pair of chromosomes in female somatic cells inactivating the Y chromosome in male somatic cells increasing gene expression from the X chromosome in male somatic cellDefine the Random Monoallelic Expression: Inactivation of the X Chromosome ?A cytogeneticist is studying the cells from an abnormal female monkey. In some cells, she finds that both X-chromosomes are active (i.e. not packaged into a Barr body), although one of the X-chromosomes appears shorter. She also finds that one of the autosomes are packaged as a Barr body, and she suspects that a translocation event might have been involved. By referring to the mechanism of X-chromosome inactivation, explain the observations made by the scientist
- Cat fur coat color genetics is interesting. Orange fur is dominant (''B'') to black fur (''b'') and piebald, which is white spotting, is dominant (''S'') to non-white-spotted (''s''). Both of those genes are located on the X chromosome. In addition, in cats, somatic cells exhibit X-inactivation randomly, which explains why there are tortoiseshell cats (when heterozygous, have orange and black spots) as well as calico cats (orange and black but also with white spots). An orange and white spotted male is mated with a tortoiseshell female. Draw a dihybrid Punnet square to show the possible offspring:+ ec +/Y + + w/Y y ec +/Y + ec +/y ec w ++ w/y ec w у ес +у ес и Determine the order in which the three loci y, ec, and w Occur on the chromosome and prepare a linkage map. 7.22 A cross involving X-linked genes was made between yellow, bar, vermilion female fies and wild males, and the F1 females were crossed with y B v males. The following phenotypes were obtained when 1000 progeny were exam- ined: Dra ord ma the 7.2 546 244 160 50 + + + + Bv y Bv y+ + y+v y B+ and an and and and +B + re + + v ge Determine the order in which the three loci occur on the chromosome and prepare a linkage map. 7.23 Female Drosophila heterozygous for ebony (e"le), scarlet (st*/st), and spineless (ss*/ss) were testcrossed, and the following progeny were obtained: PROGENCY PHENOTYPES NUMBER ir Wild type Ebony Ebony, scarlet Ebony, spineless Ebony, scarlet, spineless Scarlet 67 8. 68 347 78 368 Scarlet, spineless Spineless (a) Are these genes linked? Justify your answer. (b) Write the genes given on a…Cat fur coat color genetics is interesting. Orange fur is dominant (''B'') to black fur (''b'') and piebald, which is white spotting, is dominant (''S'') to non-white-spotted (''s''). Both of those genes are located on the X chromosome. In addition, in cats, somatic cells exhibit X-inactivation randomly, which explains why there are tortoiseshell cats (when heterozygous, have orange and black spots) as well as calico cats (orange and black but also with white spots). An orange and white spotted male is mated with a tortoiseshell female. State the genotype of the male and the female.