Steven Frank and Laurence Hurst argued that a cytoplasmically inherited mutation in humans that has severe effects in males but no effect in females will not be eliminated from a population by natural selection because only females pass on mtDNA (S. A. Frank and L. D. Hurst. 1996. Nature 383:224). Using this argument, explain why males with Leber hereditary optic neuropathy are more severely affected than females.

Biology (MindTap Course List)
11th Edition
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
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Chapter19: Evolutionary Change In Populations
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Problem 15TYU
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Steven Frank and Laurence Hurst argued that a cytoplasmically
inherited mutation in humans that has severe effects in males but no
effect in females will not be eliminated from a population by natural
selection because only females pass on mtDNA (S. A. Frank and L. D.
Hurst. 1996. Nature 383:224). Using this argument, explain why males
with Leber hereditary optic neuropathy are more severely affected than
females.

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