Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 18, Problem 30ESP
The localization and translational control of actin mRNA is important for the migration of fibroblasts and is regulated by the activity of the kinase Src (see Figure 18.10). Src is activated by phosphorylation when cell surface receptors bind to signaling molecules. How might this system lead to a cell migrating in a specific direction? How might the cell migrate away from repulsive signals?
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Students have asked these similar questions
Researchers have found that a certain signal transduction pathway, illustrated in the figure
below, may be responsible for the development of cancer in pancreatic cells. In normal
pancreatic cells, where the pathway remains inactive, a membrane-bound receptor called
Ptc inhibits a downstream protein known as Smo. The inhibition of Smo blocks the activa-
tion of a complex of proteins known as the HSC, which results in the cleaving of one of its
proteins called Ci. The cleaving of Ci, in turn, prevents the pathway from initiating the syn-
thesis of division-facilitating enzymes.
A
Ptc
B
Smo
с
inhibition
D
A model of a Ptc signal transduction pathway under normal conditions.
HSC
Ci cleavage
A certain protein called the Hedgehog protein (Hh) is found to activate this signal transduction pathway and
trigger uninterruptable cell division.
cell division not initiated
Which of the following describes the most plausible mechanism by which Hh triggers uninterruptable cell
division?
Hh binds to…
GTP binding proteins are molecular switches. How do GTP binding proteins work?
Provide two examples of GTP binding proteins that function in intracellular protein transport.
Make a drawing that illustrates the function of each of these proteins in their respective roles.
Predict the direct outcome of a mutation that:
Inhibits GTPase activity
Inhibits interaction with the GEF
3) The “Met" receptor is a membrane receptor protein responsible for initiating signal
transduction pathways that cause cells to divide, among other things.
After the Met receptor has been stimulated by its specific growth factor, another protein called c-
Cbl will bind to the Met receptor. C-Cbl will then attach a chain of small proteins called ubiquitin
to the Met receptor. These chains of ubiquitin help the cell recognize that the Met receptor should
undergo receptor-mediated endocytosis, which eventually leads to the destruction of the Met
receptor.
Circle any answer or answers that include mutations that could cause the cell to potentially
become a cancer cell.
A) a mutation causing there to be too much ubiquitin protein produced.
B) a mutation causing c-Cbl to be inactivated.
C) a mutation causing ubiquitin to be inactivated.
D) a mutation causing there to be too few Met receptors produced.
E) a mutation causing the Met receptor to no longer be able to bind to its growth factor.…
Chapter 18 Solutions
Concepts of Genetics (12th Edition)
Ch. 18 - Some mutations in the tra gene of Drosophila cause...Ch. 18 - Some scientists use the analogy that the...Ch. 18 - Consider the example that actin mRNA localization...Ch. 18 - What is alternative splicing, where does it occur,...Ch. 18 - What role might the expanded tri- and...Ch. 18 - DM1 is characterized by a phenomenon known as...Ch. 18 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 18 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 18 - List three types of alternative splicing patterns...Ch. 18 - Consider the CT/CGRP example of alternative...
Ch. 18 - Explain how the use of alternative promoters and...Ch. 18 - Explain how a tissue-specific RNA-binding protein...Ch. 18 - The regulation of mRNA decay relies heavily upon...Ch. 18 - Nonsense-mediated decay is an mRNA surveillance...Ch. 18 - AU-rich elements (AREs) are cis-elements in mRNAs...Ch. 18 - What are processing bodies (P bodies), and what...Ch. 18 - In 1998, future Nobel laureates Andrew Fire and...Ch. 18 - Present an overview of RNA interference (RNAi)....Ch. 18 - RNAi may be directed by small interfering RNAs...Ch. 18 - Prob. 14PDQCh. 18 - In principle, RNAi may be used to fight viral...Ch. 18 - Prob. 16PDQCh. 18 - Prob. 17PDQCh. 18 - Prob. 18PDQCh. 18 - Prob. 19PDQCh. 18 - How is it possible that a given mRNA in a cell is...Ch. 18 - Prob. 21PDQCh. 18 - Prob. 22PDQCh. 18 - Prob. 23PDQCh. 18 - Prob. 24ESPCh. 18 - Prob. 25ESPCh. 18 - Mutations in the low-density lipoprotein receptor...Ch. 18 - RNA helicases are a class of proteins that bind...Ch. 18 - While miRNA response elements (MREs) may be...Ch. 18 - RNAi is currently being tested as a therapeutic...Ch. 18 - The localization and translational control of...Ch. 18 - Explain how the expression of a single gene can be...
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