preview

Glt2 Task 2

Decent Essays

MBG110 04.12.2015
HOMEWORK II
Name: İsmail Serdar Taşkafa
ID: 21501927
1- (30 pts) There are many stages after transcription which regulate gene expression. What are these additional regulatory mechanisms? Describe each of these stages.
1- RNA processing: In eukaryotic cells, introns, non-coding regions of RNA, are removed and a tail and a cap is added to RNA to help its movement.
2- RNA transport: RNA is transferred from nucleus to ribosome to initiate translation.
3- Translation: According to the genetic information of mRNA, polypeptide is synthesized.
4- mRNA degradation: After translation, the used mRNA is degraded by miRNA’s.

2- (20 pts) a) What are DNA microarrays? In which areas are they used?
DNA microarray is a grid that is composed of spots that contains uniform DNA strands. DNA microarrays are used to identify which genes are expressed on a given cell type. …show more content…

RNA-Seq ( RNA sequencing) or whole transcriptome shotgun sequencing and serial analysis of gene expression (SAGE or superSAGE) can be used to detect changes in gene expression.

3- (30 pts) miRNAs, which are a class of small RNAs, can function as oncogenes or tumor suppressors in cancer. Explain one disease, other than cancer, that can be associated with miRNAs or other small RNAs.
MS (Multiple sclerosis) can be associated with miRNAs. Multiple sclerosis is a chronic, mostly progressive neurodegenerative disease that involves damaging of nerve cells’ covering. In MS, microRNAs are disregulated in the immune

Get Access