RNA

Abstract Despite the importance of RNA-protein interactions in essential biological processes, there is still only a small number of RNA-protein complexes with high resolution three dimensional structures compared to other biomolecules. In this study, we investigate RNA nucleotide base-amino acid residue interactions by counting contacts in the helical and backbone regions. Contact frequency data from non-redundant RNA-protein complexes is used to estimate relative potential energy of interactions

RNA GQ structures in cap-independent translation initiation. RNA G-quadruplex (GQ) is a secondary structure that can act as both necessary elements of translation and as translation repressors.1-3 The role of GQ structures in translational modulation depends on the context in which the GQ structure is present.4 However, it is well established that these structures mostly inhibit translation.2,5-7 In fact, rational introduction of GQ structures specifically downregulate the expression of targeted

Discovery Early evidence that a type of RNA could elicit gene silencing in animal cells came from work by Dr. Guo and Dr. Kemphues, who used antisense RNA to reduce gene expression in the nematode Caenorhabditis elegans. Later, Dr. Ambros and co-workers discovered the first miRNA, lin-4, in 1993. They identified two RNA transcripts—one small and one smaller—derived from the lin-4 locus of C. elegans. This lin-4 miRNA was discovered 3 years after the first reports of RNA silencing in plants and 2 years

from the basic light microscope to high throughput DNA sequencers along with our understanding of the world around us. RNA sequencing is inspiring scientists to push the limits of current research methods in understanding how the transcriptome shapes biology and much more. RNA sequencing is becoming one of the most significant tools in the world of modern science. RNA sequencing (RNA-Seq) is revolutionizing transcriptome studies. It’s a highly reliable tool for measuring gene expression across the transcriptome

Comparison chart | DNA | RNA | Definition: | A nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms | RNA, single-stranded chain of alternating phosphate and ribose units with the bases adenine, guanine, cytosine, and uracil bonded to the ribose. RNA molecules are involved in protein synthesis and sometimes in the transmission of genetic information. | Job/Role: | Medium of long-term storage and transmission of genetic information

Compare and contrast DNA and RNA? DNA and RNA have some similarities they both are polymer of nucleotides. Its sugar is connected to group at one end and a nitrogenos base at the other end. DNA and RNA also can be located in the nucleus. DNA stays in the nucleus while RNA can move in and out of the nucleus. The difference between DNA and RNA is DNA is double stranded and RNA is single stranded. DNA has deoxyribose sugar and RNA has ribose sugar. DNA also has thymine and RNA has uracil. DNA can undergo

Project I: RNA Self-Splicing Kit Fung (Klaus) Chan TA: Christopher Kampmeyer, Henry Sillin Lab Section: 1B T/R 4pm-7:50pm Group Member: Phuong (Nhu) Huynh Group Number: 13 Date Submitted: 4/23/2015 This is my own original work. If any portion of found not to be my own original work, I will accept zero points for this report in addition to whatever the Dean dictates.   Abstract mRNA bears the role of accurately conveying genetic information from DNA into protein (Nature), but there is an extra crucial

RNA interference pathways play an integral role in the silencing of gene expressions, predominately by destroying specific targeted molecules of messenger RNA (mRNA). Messenger RNA are single- stranded RNA molecules which move from the nucleus of the cell to the cytoplasm, while sending and receiving genetic information from DNA via ribosomes, to where the specific amino acid sequence of the protein involved in gene expression is located, as the article, “Messenger RNA - Glossary Entry” explains

followed by either the Janus kinase- signal transducers and activators of transcription pathway or the RNA Interference (RNAi) pathways. These responses follow various steps to avoid total infection; for RNAi, the RNA is split into many pieces and find the mRNA with the same sequence. The one used in this study is the RNAi pathway and DNA methylation. These epigenetic mechanisms can modify DNA and RNA sequences without altering the original sequence. The DNA methylation happens in the bee’s gene body

biology especially revelations of the RNA world. Non-coding RNAs form a major part of it. A lot more of the human genome is transcribed than as initially thought and regulation is one of the major processes the non-coding RNAs (which though transcribed do not end up producing proteins) perform. These regulatory RNAs can be small like miRNAs, siRNAs, snRNAs of the spliceosome, snoRNAs for large RNA processing etc. or they can be long as in the case of long non-coding RNAs (lncRNAs)1. Given their role in