Ph Ph CH3 ČH3 Methsuximide Ethosuximide Phensuximide (racemic) (racemic) (racemic) Following is a synthesis of phensuximide. CN Ph CHO + Ph KCN Ph CN CN NaOEt 1. NaOH, H,O H NÓ 2. НС, Н,о COOE 3. heat COOEt COOEL Benzal- Ethyl dehyde cyanoacetate (A) (В) (гасеmie) Ph Ph Ph CH,NH HOOC СООН ELOOC COOEt 'N' (C) (racemic) (D) (racemic) ČH3 Phensuximide (racemic)

Ph Ph CH3 ČH3 Methsuximide Ethosuximide Phensuximide (racemic) (racemic) (racemic) Following is a synthesis of phensuximide. CN Ph CHO + Ph KCN Ph CN CN NaOEt 1. NaOH, H,O H NÓ 2. НС, Н,о COOE 3. heat COOEt COOEL Benzal- Ethyl dehyde cyanoacetate (A) (В) (гасеmie) Ph Ph Ph CH,NH HOOC СООН ELOOC COOEt 'N' (C) (racemic) (D) (racemic) ČH3 Phensuximide (racemic)

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter31: Immunochemistry

Section: Chapter Questions

Problem 31.75P

See similar textbooks

Similar questions

The following three derivatives of succinimide are anticonvulsants and have found use in the treatment of epilepsy, particularly petit mal seizures. Ph Ph `N' `N' ČH3 ČH3 Methsuximide Ethosuximide Phensuximide Following is a synthesis of phensuximide. CN Ph CN Ph CN 1. NaOH, H2O 2. HC, Н20 NaOEt KCN Ph-CHO cOOEt H cOOEt NC COOEt 3. Нeat Ethyl cyanoacetate (A) (B) Benzaldehyde Ph Ph Ph CH;NH2 НООС СООН Et0oC COOEt `N' (C) (D) ČH3 Phensuximide Methsuximide is formed by a similar pathway to that shown for phensuximide. Draw the structure of the compound that reacts with ethyl cyanoacetate in the synthesis of methsuximide.
synthesis of suocybin NH₂ -OH L-Tryptophan, 7 OH NH2 NH2 PsiD -CO₂ Tryptamine, 6 (PsiH) [O] NH2 NH₂ OH -OH HO PsiD PsiK -CO₂ H 4-hydroxy- ATP ADP H tryptamine, 8 Norbaeocystin, 9 H 4-hydroxy-L- Tryptophan, 11 SAM PsiM) SAH HN OH O=P. O=P-O HO PsiM PsiK OH ADP ATP Psilocin, 2 SAH SAM Psilocybin, 1 Baeocystin, 10
The following three derivatives of succinimide are anticonvulsants and have found use in the treatment of epilepsy, particularly petit mal seizures. Ph. Ph `N' ČH3 ČH3 Methsuximide Ethosuximide Phensuximide Following is a synthesis of phensuximide. CN Ph CN Ph CN NaOEt KCN 1. NaOH, H2O Ph-CHO 2. HС, Н20 COOET H cOOEt NC COOEt 3. Нeat Ethyl cyanoacetate (A) (B) Benzaldehyde Ph. Ph Ph CH3NH2 НООС СООН EtOOC COOET `N' (C) (D) ČH3 Phensuximide In the conversion of (B) to (C), draw the structure of the product of step 1.
1 Norepinephrine can be metabolized to the following metabolite in two steps as shown below. What might be the enzymes (in the correct order) responsible for these biotransformations? но но но HN -OH но- но но Он OH OH norepinephrine COMT / MAO MAO / Cyp450 MAO / Aldehyde dehydrogenase Сур450 / МАО
write the mayor produob formed by the to llow ng veaction, Assume that you have enough of each reagont/ Reactant to drive bhe veactrion to Completiion. Assume bhet thore i's protic wk up alone as neee ssary mg By NaoH 아 Y>ト

Shown here is a/anglycosidic linkage. CH₂OH CH₂OH I OH Н OH Н O Alpha Beta OL- O D- О Н I ОН HO OH -О Н Н H OH OH
8 (+) CI IZ Welwitindolinone A
H,O ? ÓTs 19.
ACTIVITY-4. Refer to the structures below. Draw the Haworth formula (pyranose) -OH но H- FOH FOH- но но H- H FOH H FOH- H- CH2OH CH2OH Alpha-D- glucopyranose Beta-D-glucopyranose (Haworth) Beta-D-glucopyranose Alpha-D- glucopyranose (Haworth) ACTIVITY-5. Draw the Haworth formula for D-mannose and D-galactose. Label the alpha and beta anomer. CYCLIC FORMS OF FRUCTOSE D-fructose, a ketohexose sugar, can be presented using furanose and pyranose. Cyclic Fisher (furanose) 1 2OH Open chain Fisher Haworth formula (furanose) 1 CH2OH HOH,C- 1 2 F0 НО 3_H. ÇH2OH ÇH2OH но з—н 4 H- H но 2 H-4 HO- H- 5. OH 13 H-5 FOH 6 CH,OH 14 OH H. 6 CH2OH D-fructose Alpha form Alpha form Cyclic Fisher (pyranose) Haworth formula (pyranose) 1 HOH2C-2 3. 1 HO- CH2OH Но H. 5 он 2 H-4 HO- Но 4 OH 3 H-5 FHO- OH H-6 H Alpha form of D-fructose Alpha form of D-fructose ACTIVITY-6. Draw the Fisher and Haworth formula for beta-D-fructose (furanose and pyranose form). Label the beta furanose and beta pyranose.
6) Draw the structure of the products 23 to 27. tBuOH HO H,SO, 23 1) NaBH4 2) H20 PB13 25 24 H20, H2SO4 OMe MEOH OH KH H2SO, 26 27
An enzyme catalyzes each reaction given below. Which group does each enzyme belong to? а. pyruvate +NADH + H* → lactate + NAD* но. он он b. ethyl 2-methyl-5-thien-2-ylpentanoate + H2O → 2-methyl-5-thien-2-ylpentanoic acid + ethanol OH но
Which of the following bases are strong enough to deprotonate CH3CH2CH2C≡CH (pKa = 25) so that equilibrium favors the products: (a) H2O; (b) NaOH; (c) NaNH2; (d) NH3; (e) NaH; (f) CH3Li?