Insulin resistance

3. Skin shows slight thickening and darkening across the neck • Likely caused by a disorder called “Acanthosis Nigricans” • Could be caused by too much insulin in the bloodstream • The excess insulin could be caused by insulin resistance due to Polly’s obesity or by type two diabetes • Could be caused by oral contraceptives affecting her insulin level (Estrogen and

to produce insulin . He further addresses that there is 10-fold increase in the frequency of apoptosis in non obese type 2 diabetic mice when compared to the control(non diabetic mice) and about a 3- fold increase in obese diabetic mice when also compared with the control . The pancreatic islet has deposits of peptide, Islet amyloid polypeptide( IAPP) also known as amylin

Resting metabolic rate (RMR) as main part of daily energy expenditure (14) has principal role in energy balance. Indeed, resting metabolic rate can effect on adiposity or weight gain(14, 15). Our results demonstrated that RMR/kg had reverse significant correlation with weight, BMI and visceral fat. Some pathogenetic explanation for lower energy expenditure in obese subjects with metabolic syndrome may be the lipotoxic theory, lower levels of uncoupling proteins in mitochondria and genetic polymorphism

your blood. It means the blood sugar or blood glucose is too high. If your body doesn’t make enough insulin, or insulin doesn’t work the way it should, glucose can’t get into your cells. Instead, glucose stays in your blood. Glucose comes from the food you eat. Your blood carries glucose to all the cells in your body. These cells use glucose for energy. Insulin is a hormone made by the pancreas. Insulin enters the blood and is what is important to open the body cells so glucose can enter it. There

to hyperglycemia. Ultimately it can best be characterized as a disease of insulin resistance and progressive beta cell failure, but numerous factors contribute to each. Non-modifiable risk factors for developing type 2 diabetes include genetics and age. Beta-cell dysfunction and insulin resistance are both inheritable traits. Researches have identified some 50 loci (specific location of a gene) associated with insulin concentration and glucose, while 32 have known associations with type 2 diabetes

Introduction Metabolic syndrome is a group of conditions comprising of insulin resistance, dyslipidaemia, high blood pressure, and obesity. All these conditions or risk factors are strong causes of type 2 diabetes mellitus (Hanson et al., 2002). Henceforth, type 2 diabetes mellitus (T2DM) is a type of metabolic syndrome complication. Individuals who have T2DM are hyperglycaemic and are prone to both cardiovascular and renal diseases (Turner et al., 1998). In the past, T2DM was seen to mainly affect

phenotypes…. n Subsequent studies in animal models for insulin resistance, AD, or both, have established that insulin resistance exacerbates Aβ and tau phenotypes including enhanced Aβ 42/40 ratio, total tau, and hyperphosphorylated tau (Ho et al., 2004; Lester-Coll et al., 2006; Li et al., 2007; Masciopinto et al., 2012; Plaschke et al., 2010; Qu et al., 2011; Searcy et al., 2012; Takeda et al., 2010) and AD amyloidosis models exhibit insulin resistance (Rodriguez-Rivera et al., 2011). Our understanding

abdominal obesity, insulin resistance, dyslipidemia and increased blood pressure (Erik and Klein, 2009). the pathogensis of insulin resistance greatly linked to adipose tissue. intra-abdominal fat cells release free fatty acids and other adipocytokines which produce an inflammatory response and could have

Diabetes Q1 - Why is Type-2 diabetes and issue in our community Q2 - What is the biology behind Type-2 Diabetes? Q3 - Does Obesity cause diabetes? 2, Treat/Prevent 2, Opinion/Viewpoint Reliability Personal Opinion & what they need to change Type 2 diabetes is A very prominent issue in our community, usually it is older people who get it, however it is becoming an increasing issue as younger children are getting it. “ In 1996 approximately 81,000 people in New Zealand were known to have Type

The Pathophysiology Behind PCOS: Inflammation A Literature Review Alexandra Bailin Abstract, REFS Purpose of review Recent findings Summary Introduction Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive aged women, with a prevalence of 16.6-18% according to the 2003 Rotterdam criteria (1-3). Though PCOS is extremely common, up to 70% of women with the syndrome are undiagnosed (3). The PCOS diagnosis is one of ovarian dysfunction and hyperandrogenism, and