A Brief Note On The Major Micro Vascular Complication Of Type 2 Diabetes Mellitus

Bckground While modern lifestyles and medical care have certainly improved the longevity of humans in the developed world, and contributed to a greater quality of life scenario, those same lifestyles have engendered a number of issues that contribute to disease. Lack of proper diet, fast food, high fat and carbohydrate diets without adequate fruits and vegetables, lack of exercise, smoking and alcohol contribute to an epidemic of obesity which, in turn, contributes to a serious metabolic disorder called Diabetes Mellitus Type 2. While not managed by insulin injections, it is nevertheless quite serious and has a number of progressing symptoms that, if not treated properly, can result in cardiovascular, renal and neurological problems, as well as amputation, ocular issues, and even cognitive dysfunction.

Diabetes is a disease where the body is unable to produce or use insulin effectively. Insulin is needed for proper storage and use of carbohydrates. Without it, blood sugar levels can become too high or too low, resulting in a diabetic emergency. It affects about 7.8% of the population. The incidence of diabetes is known to increase with age. It’s the leading cause of end-stage renal disease in the US, and is the primary cause of blindness and foot and leg amputation. It is known to cause neuropathy in up to 70% of diabetic patients. Individuals with diabetes are twice as likely to develop cardiovascular disease. There are two types of diabetes: Type 1 and Type 2.

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The increase in the prevalence of type 2 diabetes is causing huge health problem through out the world including developed countries. Mostly people with low income groups are affected in developed countries (Zimmet 2001).The magnitude of the healthcare problem of type 2 diabetes results mainly from its association with obesity and cardiovascular risk factors. Indeed, type 2 diabetes has now been identified as one manifestation of the “metabolic syndrome”, a condition characterised by insulin resistance and associated with a range of cardiovascular factors (Jonathan 2003)

performed linkage and association analyses to evaluate the roles of the neuronal constitutive (NOS1) and endothelial constitutive (NOS3) nitric oxide synthase genes and the endothelin-1 (EDN-1) gene in predisposition to chronic renal failure in African Americans [47]. The study population consisted of 361 individuals from 168 multiplex African American families and an additional 92 unrelated African Americans with type 2 diabetes mellitus-associated ESRD (singletons). Microsatellite markers NOS1B (NOS1), D7S636 (NOS3) and CPHD1-1/2 (EDN-1) were genotyped in the sample. In addition, a mutation, Glu298Asp, in exon 7 of NOS3 and a 27 bp variable number tandem repeat (VNTR) marker in intron 4 of NOS3 were evaluated. After association analyses utilizing the relative predispositional effect method and model independent linkage analyses using GeneHunter-plus and MapMaker/SIBS (exclusion analysis) software, significant evidence for association with ESRD was detected for alleles 7 and 9 of the NOS1 gene (11.9 and 34.2%, respectively, in unrelated probands of ESRD families versus 6.5 and 27.5%, respectively, in race-matched controls, both P:ll see how beautiful I

This article goes in detail about the complications of Type 2 Diabetes, on how hyperglycemia damages the vascular system leading to microvascular disease and macrovascular disease. The complications of microvascular disease are diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy. On the other hand, with macrovascular disease includes Cardio Vascular Disease (CVD), such as Atherosclerosis. Furthermore, the article gives recommendations of treating Type 2 Diabetes and the prevention of its health related complications with medication, screening, diet, and exercise.

Type II Non-insulin dependent diabetes is the most common. It often occurs in older adults, patients who are overweight, and patient with metabolic disorders. It can happen at any age though. The tissues in the body have built some resistance to insulin. The insulin levels in these patients can vary from low to high and can also be normal. You might be at risk of developing Non-insulin dependent diabetes if you have a family history diabetes, being obese, not exercising enough, and your age. Rosdahl (2012) notes that Non-insulin dependent diabetes patients do not need insulin for life but May or may not need it to help control their insulin levels. Most patients

Diabetes is associated with an increased risk of developing primarily vascular complications that contribute to morbidity and mortality of diabetic patients. Poor glycaemic control leads to vascular complications that affect large (macrovascular), small (microvascular) vessels or both. Macrovascular complications include coronary heart disease, peripheral vascular disease and stroke. Microvascular complications contribute to diabetic neuropathy (nerve damage), nephropathy (kidney disease) and retinopathy (eye disease).

Diabetes mellitus (DM) is a condition in the body that is related to a faulty metabolism. It means that the body’s metabolism is not functioning properly, which leads to adverse effects in the health. The food we ingest, gets broken down into blood sugar (glucose), which is what fuels our body in the form of energy. This converted glucose needs to enter our cells so that it can be used for energy and growth. And in order for the glucose to enter our cells, there needs to be insulin present, which the beta cells of the pancreas is responsible for producing. This hormone is responsible for maintaining glucose level in the blood. It allows the body cells to use glucose as a main

This was an interventional study to understand the effect of two low-cost interventions; yoga and peer support on the quality of life (QOL) of women with type 2 diabetes.

One of the most common long-term complications of diabetes mellitus is painful neuropathy. Diabetic neuropathy is estimated to affect about 60-70% of all diabetes patients and can lead to foot ulcers, amputations, and decreased quality of life. The most common form is chronic peripheral neuropathy which results in pain and numbness in the extremities, usually described as a burning, tingling, or steady aching pain.1 Patients may also feel increased sensitivity to pain or experience paresthesia, a sensation of tingling, tickling, or prickling of the skin.1 According to current guidelines, intensive glycemic control is very important for the prevention and reduction of peripheral neuropathy and other microvascular complications.1,2 Medications used to help relieve nerve pain include duloxetine and pregabalin (Lyrica®), which are both approved by the U.S. Food and Drug Administration for use in diabetic neuropathy. Other drug classes commonly used are antidepressants, anticonvulsants, and opioids.3 Although there are many medications used for this condition, pain relief is often insufficient for patients. Treatment is difficult due to the complicated pathophysiology of pain transmission and the wide range of mechanisms of action of drugs used to treat pain. Therefore, there is a continued need for additional medication options for this chronic painful condition. Lacosamide is an anticonvulsant approved for use as monotherapy or adjunctive therapy for partial-onset seizures.

According to National Kidney Foundation (2010), the majority of people with diabetes tend to develop kidney disease. This is probably the result of poor or improper dietary and life-style practices, although genetics seem to be a factor. This makes it the single leading cause of kidney failure. High blood pressure/Hypertension is another pre-disposing factor of kidney failure. This disease is also aggravated by improper dietary and life-style practices. High blood pressure/Hypertension speeds up the loss of kidney function and eventually leads to kidney failure. It also appears to have genetic and familial factors (National Kidney Foundation, 2010).

Diabetic microvascular complications are the leading cause of blindness, end-stage renal diseases, and other neuropathies due to hypoxia and ischemia in the retina, the kidney, and nerves. Thickening of the capillary basement membrane result in decreased tissue perfusion. Many people with type 2 diabetes present with microvascular complications because of the long duration of asymptomatic hyperglycemia that usually precedes diagnosis (Mccaine and Huther).

One of the diseases is diabetes mellitus which is a major cause of renal failure. This disease can be defined as an increase of fasting blood glucose that is affected by a deficiency in insulin hormone. The normal range for glucose (fasting) in the blood is 2.8-6.0 mmol/L. It is classified into two groups, type 1 (insulin-dependent diabetes mellitus) and type 2 (non insulin-dependent diabetes mellitus). Stein (2008, p.6) points out that kidney failure happens most often when patients have suffered from diabetes mellitus for more than 10 years. According to United States Renal Data System (USRDS) report in 2007, approximately 44% of primary causes of renal failure is diabetes mellitus in the United States in 2005. Also, Stein (2008) indicates that 15% of dialysis patients are influenced by diabetes mellitus in the United Kingdom. Diabetes mellitus has negative affects throughout the kidneys where the increase of the range of blood sugar causes the damages to the cells in the kidneys. This leads to the presence of the glucose in the urine which is known as glycosuric.

Diabetes is highly prevalent condition, affecting 8.2 % of adults globally or 382 million people. Incidence is increasing with a estimated global prevalence of 592 million people by 2035. It further results in Chronic kidney disease & further may lead to ESKD(End-Stage Kidney Disease).