Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 14, Problem 10TYK
Summary Introduction
To review:
The data that was available to Watson and Crick, other than Chargaff’s data, which suggested that adenine–guanine and cytosine–thymine pairs do not form normally.
Introduction:
Watson and Crick proposed the DNA (deoxyribonucleic acid) model, according to which a DNA molecule consists of two chains of polynucleotides wound around each other in the form of a double helix. Each monomer in the chain consists of deoxyribose, a phosphate group, and a nitrogen base. There are four nitrogenous bases in DNA, of which two are purines and two are pyrimidines.
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Students have asked these similar questions
State the properties of the Watson-Crick model of DNA in the following categories:
a) number of polynucleotide chains
b) polarity (strand direction running same or opposite
c) bases on interior or exterior of molecule
d) sugar/phosphate on interior or exterior of molecule
e) which bases pair with which
f) right- or left-handed helix
In the Watson-Crick model for the DNA double helix (B form) the A-T and G-C base pairs share all
but one of the following properties. Which is the exception?
None of the proton-binding groups in the purine and pyrimidine bases is in its charged or ionized form.
The plane of the base pair is roughly perpendicular to the axis of the helix in each case.
The number of hydrogen bonds formed between the two bases of the base pair is the same.
O The distance between the two glycosidic (base-sugar) bonds is the same in both base pairs, within a few
tenths of an angstrom.
You are studying COVID-19 which infects bat cells through an interaction between a lysine residue on a viral protein with an aspartic acid residue on the bat cell protein. You discover that when the virus made the jump into human cells, the virus mutated the lysine residue to leucine. Based on your knowledge of amino acid chemistry, which amino acid(s) will the leucine most likely interact with? Briefly explain your answer.
Chapter 14 Solutions
Biology: The Dynamic Science (MindTap Course List)
Ch. 14.1 - Prob. 1SBCh. 14.2 - Prob. 1SBCh. 14.2 - Prob. 2SBCh. 14.2 - Prob. 3SBCh. 14.2 - Prob. 4SBCh. 14.3 - What is the importance of complementary base...Ch. 14.3 - Why is a primer needed for DNA replication? How is...Ch. 14.3 - DNA polymerase III and DNA polymerase I are used...Ch. 14.3 - Prob. 4SBCh. 14.4 - Why is a proofreading mechanism important for DNA...
Ch. 14 - Working on the Amazon River, a biologist isolated...Ch. 14 - Prob. 2TYKCh. 14 - Pyrimidines built from a single carbon ring are:...Ch. 14 - Which of the following statements about DNA...Ch. 14 - Which of the following statements about DNA is...Ch. 14 - Prob. 6TYKCh. 14 - Prob. 7TYKCh. 14 - Prob. 8TYKCh. 14 - Prob. 9TYKCh. 14 - Prob. 10TYKCh. 14 - Discuss Concepts Eukaryotic chromosomes can be...Ch. 14 - Prob. 12TYKCh. 14 - Prob. 13TYKCh. 14 - Discuss Concepts During replication, an error...Ch. 14 - Design an Experiment Design an experiment using...Ch. 14 - Prob. 16TYKCh. 14 - Prob. 1ITDCh. 14 - Prob. 2ITD
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- Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which prevent ions from moving across cell membranes. Normally there are channel proteins that allow passage of the ions, but in patients with one kind of CF these proteins seem odd. Closer examination shows that these proteins display the correct amino acid sequence. However, they fail to do their job. A) Given that the primary structure of the protein is correct, what can you infer about the DNA sequence for the gene coding this protein on this patient, is there a mutation? Explain. B) Why is the primary structure insufficient to guarantee the proper function of the protein?arrow_forwardBelow are shown two views of the backbone representation of the Myc-Max complex binding to DNA (PDB ID: 1NPK). Myc and Max are members of the basic helix-loop-helix (BHLH) class of DNA- binding proteins (see Chapter 29). Myc (red) and Max (blue) associ- ate via a coiled-coil interaction and bind DNA as a dimer. Side view of Myc-Max bound to DNA Top view of Myc-Max bound to DNA (looking down the DNA helical axis) (a) Are the helices bound to the DNA likely to be amphiphilic? Explain. (b) Where do you predict the N- and C-termini are located for Max?arrow_forwardUsing a table that shows which codon represents which amino acid determine the following: A) The possible codons that encode Serine: B) The amino acids that could be encoded if the 2nd position of the UCA codon that encodes Serine was changed to one of the other 3 bases: C) The amino acids that could be encoded if the 3rd position of the UCA codon that encodes Serine was changed to one of the other 3 bases: D) The amino acids that could be encoded if the 1st position of the UCA codon that encodes Serine was changed to one of the other 3 bases:arrow_forward
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